| Identification | Back Directory | [Name]
Abacavir Related CoMpound D | [CAS]
1443421-69-9 | [Synonyms]
Abacavir EP Imp B
Abacavir Impurity D
Abacavir Impurity B
Abacavir EP Impurity B
Abacavir Related CoMpound D
O-Pyrimidine Derivative Abacavir (USP)
Abacavir Impurity 2(Abacavir EP Impurity B)
Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine
N6-Cyclopropyl-9-{(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yloxy)methyl]cyclopent-2-enyl}-9H-purine-2,6-diamine
6-(Cyclopropylamino)-9-[(1R,4S)-4-[[(2,5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine
9H-Purine-2,6-diamine, N6-cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4-pyrimidinyl)oxy]methyl]-2-cyclopenten-1-yl]-
6-N-Cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4- pyrimidinyl)oxy]methyl]cyclopent-2-en-1-yl]-9H-purine-2,6- diamine | [Molecular Formula]
C18H21ClN10O | [MDL Number]
MFCD28137825 | [MOL File]
1443421-69-9.mol | [Molecular Weight]
428.88 |
| Hazard Information | Back Directory | [Uses]
Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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