Hexachlorophene
Product identifier
- Product name: Hexachlorophene
- CBnumber: CB8687902
- CAS: 70-30-4
- EINECS Number: 200-733-8
- Synonyms: Hexachlorophene,Fomac
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
Label elements
Pictogram(s)
- Signal wordDanger
H225 Highly Flammable liquid and vapour
H370 Causes damage to organs
H410 Very toxic to aquatic life with long lasting effects
H411 Toxic to aquatic life with long lasting effects
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P501 Dispose of contents/container to..…
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P391 Collect spillage.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: Hexachlorophene
- Synonyms: Hexachlorophene,Fomac
- CAS: 70-30-4
- EC number: 200-733-8
- MF: C13H6Cl6O2
- MW: 406.9
Description of first aid measures
If inhaledFresh air, rest.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Rinse with plenty of water (remove contact lenses if easily possible).
Rinse mouth. Rest. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
Most important symptoms and effects, both acute and delayed
Inhalation of dust is poisonous; irritating to mucous membranes. Eye and skin irritant. Poisonous if swallowed. Symptoms following ingestion include anorexia, nausea, vomiting, abdominal cramps, and diarrhea. Dehydration may be severe and may be associated with shock. (USCG, 1999)
Indication of any immediate medical attention and special treatment needed
Other therapies. Though this compound is quite toxic systemically and enhanced clearance methods would appear beneficial, there is no evidence to support the efficacy of hemodialysis, peritoneal dialysis, hemoperfusion, or exchange transfusion.
Extinguishing media
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical or carbon dioxide. Keep run-off waste out of sewers and water sources.
Specific Hazards Arising from the Chemical
Special Hazards of Combustion Products: Contain toxic and irritating chloride fumes. Behavior in Fire: Decomposes to produce toxic and irritating gases. (USCG, 1999)
Advice for firefighters
Use water spray, powder, foam, carbon dioxide.
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Store at room temperature up to 25 deg C (77 deg F).
Control parameters
Occupational Exposure limit valuesno data available
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear face shield.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical statecrystalline
- Colouroff-white to tan
- Odour
ODORLESS OR HAS ONLY SLIGHTLY PHENOLIC ODOR
- Melting point/freezing point
160 - 166°C
- Boiling point or initial boiling point and boiling range
166°C
- Flammability
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
- Lower and upper explosion limit/flammability limit
no data available
- Flash point
238.6°C
- Auto-ignition temperature
no data available
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility
less than 1 mg/mL at 68° F (NTP, 1992)
- Partition coefficient n-octanol/water
7.54 (calculated)
- Vapour pressure
8.3X10-11 mm Hg at 25 deg C (est)
- Density and/or relative density
1.713g/cm3
- Relative vapour density
no data available
- Particle characteristics
no data available
Reactivity
Decomposes on heating and on burning. This produces toxic and irritating fumes including hydrogen chloride. Reacts with strong oxidants.
Chemical stability
no data available
Possibility of hazardous reactions
HEXACHLOROPHENE is incompatible with strong oxidizers. It forms salts with alkalis and alkaline earths. (NTP, 1992)
Conditions to avoid
no data available
Incompatible materials
Oxidizers.
Hazardous decomposition products
When heated to decomposition, it emits highly toxic fumes of ... /hydrogen chloride/.
Acute toxicity
- Oral: LD50 Rat oral 56 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Classification of carcinogenicity: 1) evidence in humans: no data; 2) evidence in animals: inadequate. Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. From table
Reproductive toxicity
no data available
STOT-single exposure
The substance may cause effects on the nervous system and optic nerve. This may result in cardiac disorders, respiratory failure and blindness. The effects may be delayed up to 48 hours. Medical observation is indicated.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the nervous system and optic nerve. This may result in tissue lesions and blindness. May cause toxicity to human reproduction or development.
Aspiration hazard
A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.
Toxicity
- Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow) age 30 days, length 20.1 mm, weight 0.103 g; Conditions: freshwater, flow through, 24.3 deg C, pH 7.30, hardness 51.1 mg/L CaCO3, alkalinity 45.8 mg/L CaCO3, dissolved oxygen 5.8 mg/L; Concentration: 21 ug/L for 96 hr (95% confidence interval: 19-23 ug/L) /99% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr neonate; Conditions: freshwater, static, 21 deg C, pH 7.6; Concentration: 0.000487 mM for 24 hr; Effect: intoxication, immobilization
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Hexachlorophene, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Radio-labeled C14-hexachlorophene was not biodegraded in surface water from the Skidaway River, GA(2). In sediments from Skidaway River, radio-labeled C14-hexachlorophene was degraded with a half-life of 290 days(2).
Bioaccumulative potential
The BCF of hexachlorophene in carp (Cyprinus carpio), exposed for 8 weeks to 2 and 0.2 ug/L were 87-148 and 82-153, respectively(1). BCFs for hexachlorophene in mosquito fish (Gambusia affinis) and snails (Physa sp) are 278 and 970, respectively(2). According to a classification scheme(3), these BCFs suggest the potential for bioconcentration in aquatic organisms is moderate to high(SRC).
Mobility in soil
The Koc of hexachlorophene has been reported as 91,000(1). According to a classification scheme(2), this Koc value suggests that hexachlorophene is expected to be immobile in soil. The pKa of hexachlorophene is 4.95(3), indicating that this compound will partially exist in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). A study of the mobility in Hagerstown silty clay loam soil TLC (thin layer chormatography) plates using 10 soil fungi and an alga (range of Rf values, 0.01-0.04, avg 0.01) indicated very little movement on the soil TLC plates(5). A monitoring study identified hexachlorophene in humic acid fractions of two sediment samples taken at least eight years after the FDA ban on the over-the-counter sale of cosmetics and drugs containing more than 0.1% hexachlorophene(6). These data indicate that hexachlorophene was strongly associated with organic matter which may have been as a result of covalent binding of the ionizable compound(5-6).
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN2875 (For reference only, please check.)
IMDG: UN2875 (For reference only, please check.)
IATA: UN2875 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: HEXACHLOROPHENE (For reference only, please check.)
IMDG: HEXACHLOROPHENE (For reference only, please check.)
IATA: HEXACHLOROPHENE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.