p-Cresol
Product identifier
- Product name: p-Cresol
- CBnumber: CB5453502
- CAS: 106-44-5
- EINECS Number: 203-398-6
- Synonyms: p-Cresol,4-methylphenol
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Skin corrosion, Sub-category 1B
Label elements
Pictogram(s)
- Signal wordDanger
H301 Toxic if swalloed
H311 Toxic in contact with skin
H314 Causes severe skin burns and eye damage
H318 Causes serious eye damage
H331 Toxic if inhaled
H351 Suspected of causing cancer
H370 Causes damage to organs
H372 Causes damage to organs through prolonged or repeated exposure
H373 May cause damage to organs through prolonged or repeated exposure
H401 Toxic to aquatic life
H412 Harmful to aquatic life with long lasting effects
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: p-Cresol
- Synonyms: p-Cresol,4-methylphenol
- CAS: 106-44-5
- EC number: 203-398-6
- MF: C7H8O
- MW: 108.14
Description of first aid measures
If inhaledFresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.
Most important symptoms and effects, both acute and delayed
no data available
Indication of any immediate medical attention and special treatment needed
no data available
Extinguishing media
Use dry chemical, carbon dioxide or alcohol-resistant foam.
Specific Hazards Arising from the Chemical
Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 86°C explosive vapour/air mixtures may be formed.
Advice for firefighters
Use water spray, foam, powder, carbon dioxide.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance and chemical protection suit. Sweep spilled substance into containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
NO open flames. Above 86°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
Control parameters
Occupational Exposure limit valuesTLV: 20 mg/m3, as TWA; (skin); A4 (not classifiable as a human carcinogen).EU-OEL: 22 mg/m3, 5 ppm as TWA.MAK: skin absorption (H); carcinogen category: 3A
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateCrystalline Solid or Liquid
- ColourColorless to light yellow, may darken on exposure to light
- Odour
no data available
- Melting point/freezing point
35.5 °C. Atm. press.:1 013 hPa.
- Boiling point or initial boiling point and boiling range
201.9 °C. Atm. press.:1 013 hPa.
- Flammability
no data available
- Lower and upper explosion limit/flammability limit1%(V)
- Flash point
86 °C. Atm. press.:1 013 hPa.
- Auto-ignition temperature
558 °C. Atm. press.:1 013 hPa.
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
no data available
- Solubility20g/l
- Partition coefficient n-octanol/water
log Pow = 1.94.
- Vapour pressure1 mm Hg ( 20 °C)
- Density and/or relative density1.0341 (20/4℃)
- Relative vapour density1.0341 (20/4℃)
- Particle characteristics
no data available
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
Reacts violently with strong oxidants. The solution in water is a weak acid.
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
no data available
Acute toxicity
- Oral: LD50 - rat (male) - 207 mg/kg bw. Remarks:Hypoactivity, tremor, lacrimation, dyspnea, hemorrhagic rhinitis, conculsion, prostration.
- Inhalation: LC50 - rat (male) - > 0.71 mg/L air.
- Dermal: LD50 - rabbit - ca. 301 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. The substance may cause effects on the central nervous system. This may result in lowering of consciousness. The substance may cause effects on the blood. This may result in destruction of blood cells. Exposure far above the OEL could cause death. Medical observation is indicated.
STOT-repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the nervous system. This may result in impaired functions. The substance may have effects on the blood. This may result in anaemia.
Aspiration hazard
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C.
Toxicity
- Toxicity to fish: LC50 (Salmo trutta) - see results - 4.7 mg/L - 6 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 7.7 mg/L - 48 h.
- Toxicity to algae: EC10 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 2.3 mg/L - 48 h.
- Toxicity to microorganisms: IC50 - activated sludge of a predominantly domestic sewage - 439.5 mg/L - 2 h. Remarks:Respiration rate.
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN3455 (For reference only, please check.)
IMDG: UN3455 (For reference only, please check.)
IATA: UN3455 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: CRESOLS, SOLID (For reference only, please check.)
IMDG: CRESOLS, SOLID (For reference only, please check.)
IATA: CRESOLS, SOLID (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.