BIS-Tris
Product identifier
- Product name: BIS-Tris
- CBnumber: CB4304881
- CAS: 6976-37-0
- EINECS Number: 230-237-7
- Synonyms: bis-tris,2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
Substance
- Product name: BIS-Tris
- Synonyms: bis-tris,2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
- CAS: 6976-37-0
- EC number: 230-237-7
- MF: C8H19NO5
- MW: 209.24
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx) Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
Advice for firefighters
In the event of fire, wear self-contained breathing apparatus.
Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
No data available
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Appropriate engineering controlsChange contaminated clothing. Wash hands after working with substance.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Full contact Material: Viton?
Minimum layer thickness: 0,7 mm Break through time: 480 min
Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Splash contact Material: Nitrile rubber
Minimum layer thickness: 0,4 mm Break through time: 30 min
Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)
protective clothing
required when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Do not let product enter drains.
Information on basic physicochemical properties
- Appearancewhite Crystalline powder
- OdourNo data available
- Odour ThresholdNo data available d) pH 9,5 - 11,0 at 209,2 g/l at 25 °C Melting point/freezing point Initial boiling point and boiling range ca.104 °C at ca.1.013,25 hPa - OECD Test Guideline 102 No data available Flash point No data available Evaporation rate No data available Flammability (solid, gas) Upper/lower flammability or explosive limits The product is not flammable. - Flammability (solids) No data available Vapour pressure No data available Vapour density No data available Relative density ca.1,4 g/cm3 at 20,3 °C Water solubility ca.579,9 g/l at 20 °C - OECD Test Guideline 105 Partition coefficient: n-octanol/water Autoignition temperature Decomposition temperature log Pow: -2,26 at 20 °C - Bioaccumulation is not expected. >400 °C - Relative self-ignition temperature for solidsdoes not ignite ca.250 °C - Viscosity No data available Explosive properties No data available Oxidizing properties No data available
- Melting point/freezing pointca.104 °C at ca.1.013,25 hPa - OECD Test Guideline 102
- Initial boiling point and boiling range104 °C(lit.)
- Flash point466.2±40.0 °C(Predicted)
- Evaporation rateNo data available
- Flammability (solid, gas)The product is not flammable. - Flammability (solids)
- Upper/lower flammability or explosive limitsNo data available
- Vapour pressure No data available
- Vapour density No data available
- Relative densityca.1,4 g/cm3 at 20,3 °C
- Water solubilityca.579,9 g/l at 20 °C - OECD Test Guideline 105
- Partition coefficient: n-octanol/waterlog Pow: -2,26 at 20 °C - Bioaccumulation is not expected.
- Autoignition temperature>400 °C - Relative self-ignition temperature for solidsdoes not ignite
- Decomposition temperatureca.250 °C -
- ViscosityNo data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
- λmaxλ: 280 nm Amax: 0.15
Other safety information
Surface tension ca.67,2 mN/m at 1,01g/l at 20 °C
- OECD Test Guideline 115
Reactivity
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
No data available
Conditions to avoid
no information available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx)
Other decomposition products - No data available In the event of fire: see section 5
Information on toxicological effects
Acute toxicityResult: No irritation - 15 min (OECD Test Guideline 439)
Result: Causes serious eye damage. - 6 h (OECD Test Guideline 492)
Escherichia coli/Salmonella typhimurium Result: negative
Mutagenicity (mammal cell test): micronucleus. Human lymphocytes
Result: negative
In vitro mammalian cell gene mutation test Chinese hamster fibroblasts
Result: Positive results were obtained in some in vitro tests.
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Toxicity
static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h (OECD Test Guideline 202)
(OECD Test Guideline 201)
Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 11,89 % - Not readily biodegradable. (OECD Test Guideline 301B)
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
No data available
Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
Further information
Not classified as dangerous in the meaning of transport regulations.
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.