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Archives of dermatology

Archives of dermatology

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Octocrylene, an emerging photoallergen.

Published:1 July 2010 DOI: 10.1001/archdermatol.2010.132 PMID: 20644036
Martine Avenel-Audran, Hervé Dutartre, An Goossens, Michel Jeanmougin, Christelle Comte, Claire Bernier, Lamia Benkalfate, Maryse Michel, Marie Christine Ferrier-Lebou?dec, Martine Vigan, Jean Luc Bourrain, Omar Outtas, Jean Louis Peyron, Ludovic Martin

Abstract

Background: Octocrylene is a new emerging photoallergen. We report and discuss 50 cases of photoallergic contact dermatitis from octocrylene use and/or positive photopatch test reactions to this UV filter and draw attention to the unexpected association in adults with a history of photoallergic contact dermatitis from ketoprofen.

Observations: Patients were divided in 3 groups: group A comprised 11 children; group B, 28 adults with a history of photoallergy from sunscreen products; and group C, 14 adults systematically tested with octocrylene because of a history of photoallergy from ketoprofen. All patients but 3 in group C had positive test reactions to octocrylene. Ten of 11 children in group A and 9 of 28 adults in group B had positive patch test reactions to octocrylene. One child in group A, the other 19 adults in group B, and 11 of 14 adults in group C had positive photopatch test reactions to octocrylene. All adults in group C and 24 of 28 adults in group B had a history of photoallergy from ketoprofen and positive patch test or photopatch test reactions to other allergens that are often positive in patients with photoallergy from ketoprofen, especially fragrance components.

Conclusions: Octocrylene appears to be a strong allergen leading to contact dermatitis in children and mostly photoallergic contact dermatitis in adults with an often-associated history of photoallergy from ketoprofen. Patients with photoallergy from ketoprofen frequently have positive photopatch test reactions to octocrylene. These patients need to be informed of sunscreen products not containing octocrylene, benzophenone-3, or fragrances.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
UV absorber UV-9 131-57-7 C14H12O3 787 suppliers $5.00-$566.00
Ketoprofen 22071-15-4 C16H14O3 755 suppliers $5.00-$3465.00
Octocrylene 6197-30-4 C24H27NO2 489 suppliers $5.00-$7507.50

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