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Journal of the American Academy of Dermatology

Journal of the American Academy of Dermatology

IF: 12.8
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The importance of dual 5α-reductase inhibition in?the?treatment of male pattern hair loss: Results?of?a?randomized placebo-controlled study?of?dutasteride versus finasteride

Published:1 December 2006 DOI: 10.1016/j.jaad.2006.05.007 PMID: 17110217
Elise A. Olsen MD , Maria Hordinsky MD , David Whiting PhD , Dow Stough MD , Stuart Hobbs PharmD , Melissa L. Ellis PharmD , Timothy Wilson MS , Roger S. Rittmaster MD , for the Dutasteride Alopecia Research Team

Abstract

Background

Male pattern hair loss (MPHL) is a potentially reversible condition in which dihydrotestosterone is an important etiologic factor.

Objective

Our aim was to evaluate the efficacy of the type 1 and 2 5α-reductase inhibitor dutasteride in men with MPHL.

Methods

Four hundred sixteen men, 21 to 45 years old, were randomized to receive dutasteride 0.05, 0.1,?0.5 or 2.5 mg, finasteride 5 mg, or placebo daily for 24 weeks.

Results

Dutasteride increased target area hair count versus placebo in a dose-dependent fashion and dutasteride 2.5 mg was superior to finasteride at 12 and 24 weeks. Expert panel photographic review and investigator assessment of hair growth confirmed these results. Scalp and serum dihydrotestosterone levels decreased, and testosterone levels increased, in a dose-dependent fashion with dutasteride.

Limitations

The study was limited to 24 weeks.

Conclusion

Dutasteride increases scalp hair growth in men with MPHL. Type 1 and type 2 5α-reductase may be important in the pathogenesis and treatment of MPHL.

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Finasteride 98319-26-7 C23H36N2O2 804 suppliers $26.00-$845.00
Dutasteride 164656-23-9 C27H30F6N2O2 624 suppliers $50.00-$1732.50
Testosterone 58-22-0 C19H28O2 468 suppliers $25.00-$623.00
Stanolone 521-18-6 C19H30O2 293 suppliers $30.00-$1318.00

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