Cycloheximide is pharmacologically active and acts similarly to reserpine. A single dose administered orally or intravenously causes an increase in blood pressure; in this case, the mechanism of action is the release of norepinephrine from tissues of the nervous system. Studies have shown that peak cycloheximide blood levels of 0.5- 0.7 mg/L after a single oral dose in humans are sufficient to cause a significant increase in blood pressure.

In addition, prolonged exposure to cycloheximide-exposed areas may result in: (1) Methemoglobinemia - increased methemoglobin in the blood; this compound is classified as a secondary toxic effect. (2) Dermatotoxin - Skin burns. (3) Skin sensitiser - a substance that induces an allergic skin reaction. (4) Toxic Pneumonia - Inflammation of the lungs caused by inhalation of metal fumes or toxic gases and vapours.

References:

[1] COLLINGS A J. Metabolism of cyclamate and its conversion to cyclohexylamine.[J]. Diabetes Care, 1989, 12 1: 50-55; discussion 81-2. DOI:10.2337/diacare.12.1.50.