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Product name
CBS Polyclonal Antibody
Isotype
IgG
Form
Lyophilized or Liquid
Tested applications
WB,IF,ELISA,IHC
Species reactivity
Human,Mouse
Host Species
Rabbit
Purity
Affinity purification
Immunogen Information:
Immunogen
Recombinant protein of human CBS
Calculated molecular weight
60kDa/61kDa
Observed molecular weight?
61kDa
Swiss Prot
P35520
Gene ID (NCBI)
875
Alternative Names
HIP4
Application Notes:
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
1:500 - 1:2000
IF
1:50 - 1:200
IHC
1:50 - 1:500
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Western blot analysis of extracts of various cell lines, using CBS antibody.
Immunofluorescence analysis of U2OS cells using CBS antibody.
Background:
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene.?
Storage:
Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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