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Foretinib,Foretinib

Foretinib

價格 詢價
包裝 5mg/50mg/200mg
最小起訂量 5mg/50mg/200mg
發(fā)貨地 北京
更新日期 2012-05-28

產(chǎn)品詳情

中文名稱:Foretinib英文名稱:Foretinib
CAS:849217-64-7有效期: 一個月
2012-05-28 Foretinib Foretinib RMB 一個月

Foretinib (GSK1363089, XL880) is a novel MET and VEGFR2/KDR kinases inhibitor with an IC50 of 0.4 and 0.8 nM for MET and KDR, respectively. Foretinib (GSK1363089, XL880) inhibits HGF receptor family tyrosine kinases with an IC50 of 3 nM for Ron. Foretinib (GSK1363089, XL880) also inhibits KDR, Flt-1, and Flt-4 with IC50 of 0.9, 6.8 and 2.8 nM, respectively. In addition, EXEL-2880 inhibits members of the platelet-derived growth factor receptor family and the angiopoietin-1 receptor Tie-2. Foretinib (GSK1363089, XL880) exhibits modest activity against fibroblast growth factor receptor 1 and epidermal growth factor receptor and is inactive against 50 serine/threonine kinases, including cyclin-dependent kinases and protein kinase C isoforms. To delineate the cellular effect of foretinib (GSK1363089, XL880), VEGF- induced extracellular signal-regulated kinase phosphorylation was used to assess the effect of the compound on phosphorylation of KDR in human umbilical vein endothelial cells that resulted in an IC50 of 16 nM. Foretinib(GSK1363089, XL880) is the 1st orally available small molecule inhibitor of Met to enter the clinic and appears to be generally well tolerated. Anti-tumor activity has been observed and Foretinib may represent an active treatment option for patients with papillary renal-cell carcinoma.

關(guān)鍵字: c-Met Inhibitors;Foretinib

公司簡介

Selleckchemicals is one of the world leading suppliers of high-performance life-science products. We have over 8,000 products which consist of inhibitors, antibodies, RNAis, proteins and peptides which focus on signaling pathways such as MAPK, PI3K/Akt, and apoptosis etc. Furthermore, compound libraries for high-throughput screening and high-content screening are also available.
成立日期 注冊資本
員工人數(shù) 年營業(yè)額
主營行業(yè) 經(jīng)營模式
  • Selleckchem LLC
非會員
  • 公司成立:暫無
  • 注冊資本:暫無
  • 企業(yè)類型:暫無
  • 主營產(chǎn)品:暫無
  • 公司地址:2626 South Loop West, Suite 225, Houston, TX 77054 USA
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