Mycophenolic acid 霉酚酸 麥可酚酸
Mycophenolic acid
Mycophenolic acid
M3536 - powder, BioReagent, suitable for cell culture, ≥98%
CAS：24280-93-1
分子式：C17H20O6
分子量：320.3
外觀：白色，乳白色粉末
純度：>；=98％
溶解性：溶于甲醇，乙醇；微溶于醚，氯仿；難溶于苯，甲苯；幾乎不溶于冷水。
儲(chǔ)存： 4℃保存5年
用途：來源于Penicillium stoloniferum及類似菌株的一類抗生素/抗菌藥。能在體內(nèi)通過抑制次黃〔嘌呤核〕苷酸脫氫酶的作用阻斷嘌呤核苷酸的合成。阻止T細(xì)胞，淋巴細(xì)胞的分裂及B細(xì)胞中抗體的形成從而作為一種免疫抑制因子。在分子生物學(xué)中用于篩選含大腸桿菌黃嘌呤鳥嘌呤磷酸核糖轉(zhuǎn)移酶基因的細(xì)胞。
參考資料：
霉酚酸
M3536-50MG 981.63 SIGMA原裝北京現(xiàn)貨銷售
M3536-250MG 3,383.64 SIGMA原裝北京現(xiàn)貨銷售
別名: 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid, 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid，麥可酚酸
溶解：
methanol: soluble50 mg/mL (Stock solutions should be stored at 2-8°C.)
Application
Recommended for use as a selection agent at 25 μg/ml.
Used to select animal cells expressing the Escherichia coli gene for xanthine-guanine phosphosribosyl transferase.
Biochem/physiol Actions
Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.
Immunosuppressive agent. Used to inhibit early stage biosynthesis of purine nucleotides. Used as a specific inhibitor of inosine 5′-monophosphate (IMP) dehydrogenase (IMPDH) and inducer of IMP dehydrogenase gene expression.
Mode of Action: Blocks inosine monophosphate dehydrogenase in the guanosine monophosphate pathway.
關(guān)鍵字： 霉酚酸;Mycophenolic acid;24280-93-1;M3536;SIGMA