Product Name: Y-27632 dihydrochloride; Y-27632 2HCl
CAS No.: 129830-38-2
Chemical Name: Trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride;Y-27632 dihydrochloride;(+)-trans-N-(4-Pyridyl)-4-[(R)-1-aminoethyl]cyclohexanecarboxamide dihydrochloride; trans-4-[(R)-1-Aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride;Y-27632 2HCl
Molecular Formula: C14H21N3O.2HCl
Molecular Weight: 320.26
Appearance: White solid
Purity(HPLC): >99%
Biological Activity: Selective p160ROCK inhibitor (Ki values are 0.14, 26, 25 and > 250 μM for p160ROCK, PKC, PKA and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Smooth muscle relaxant and orally active in vivo. Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation. Also optimizes na?ve human pluripotent stem cell growth and viability following na?ve cell derivation from primed ESCs and iPSCs using na?ve human stem cell medium (NHSM).
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