3,4-二羥基苯甲酸|T0562

價(jià)格	￥333
包裝	200mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:3,4-二羥基苯甲酸	英文名稱:Protocatechuic acid
CAS:99-50-3	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.85%	產(chǎn)品類別: 抑制劑
貨號(hào): T0562

Product Introduction

Bioactivity

名稱	Protocatechuic acid
描述	Protocatechuic acid (3, 4-Dihydroxybenzoic acid) (3, 4-dihydroxybenzoic acid) is a natural phenolic compound found in many edible and medicinal plants. Recent studies indicate that it could be used as a protective agent against cardiovascular diseases and neoplasms. The mechanism of its action is mostly associated with antioxidant activity, including inhibition of generation as well as scavenging of free radicals and up-regulating enzymes which participate in their neutralization.
細(xì)胞實(shí)驗(yàn)	Protocatechuic acid is dissolved in DMSO. Dilutions of Protocatechuic acid (2, 5, 10, 20, 50, and 100 μM) are prepared from stock solutions, with serum-free culture medium. Equal volumes of each solution are mixed with Aβ1-42 (10 μM), then incubated for 24 h on a thermoblock, with continuous agitation, and then exposed to PC12 cells for 24 h to test whether Protocatechuic acid can prevent cell death triggered by Aβ. Cell viability is determined by MTT reduction assay. Cells are treated with 200 μL per well of MTT solution (final concentration, 0.5 mg/mL in DMEM-Glutamax medium) for 3 h, at 37°C, with 5% CO2. The dark blue formazan crystals that formed are solubilized with 100 μL per well of DMSO, for 30 min. Absorbance is measured at 540 nm, with a microplate reader. Results are expressed as the percentage of MTT reduction in relation to the absorbance of control cells at 100%.
激酶實(shí)驗(yàn)	AChE activity investigation is carried out in a reaction mixture containing 50 μL of tissue homogenate, 50 μL of 5, 5'-dithiobis-(2-nitrobenzoic) acid (DTNB), 1175 μL of 0.1 M phosphate-buffered solution, pH 8.0. After incubation for 20 min at 25°C, 25 μL of acetylthiocholine iodide solution is added as the substrate. The AChE activity is determined as changes in absorbance reading at 412 nm for 3 min at 25°C and using a UV/Visible spectrophotometer.
體外活性	Protocatechuic acid 抑制Aβ和αS的聚集，破壞其已形成的纖維結(jié)構(gòu)，預(yù)防由Aβ和αS誘導(dǎo)的毒性引起的PC12細(xì)胞死亡[3]。
體內(nèi)活性	Protocatechuic acid 能在不改變小鼠運(yùn)動(dòng)活動(dòng)的情況下，防止應(yīng)激誘導(dǎo)的強(qiáng)迫游泳試驗(yàn)中的靜止時(shí)間。此外，Protocatechuic acid 還能減輕 ARS 小鼠血清皮質(zhì)酮的升高和脂質(zhì)過氧化反應(yīng)，并恢復(fù)大腦皮層和海馬中的酶抗氧化劑[1]。給大鼠注射鎘并用前列腺素和Protocatechuic acid （10-20 mg/kg）治療后，其 BChE 活性明顯降低。鎘和前列腺素或Protocatechuic acid （10-20 mg/kg）處理大鼠后，MDA 水平明顯下降[2]。
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 5 mg/mL (32.44 mM), Sonication is recommended. DMSO : 55 mg/mL (356.86 mM)
關(guān)鍵字	Endogenous Metabolite \| Inhibitor \| Protocatechuic acid \| inhibit
相關(guān)庫	神經(jīng)保護(hù)化合物庫 \| 微生物天然產(chǎn)物庫 \| 經(jīng)典已知活性庫 \| 植物來源化合物庫 \| 古代經(jīng)典名方目錄分子庫 \| 苗藥化合物庫 \| 藥食同源庫 \| 中藥單體化合物庫 \| 天然產(chǎn)物庫 \| 中藥抗炎分子庫

關(guān)鍵字：原兒茶酸|||Protocatechuate|||3,4-二羥基苯甲酸|||3,4-Dihydroxybenzoic acid|||3, 4-Dihydroxybenzoic acid|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

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公司成立：12年
注冊(cè)資本：566.2651萬人民幣
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主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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