環(huán)黃芪醇|T5575

價(jià)格	￥395.00	￥361.00	￥660.00	￥285.00	￥1450.00	￥973.00
包裝	10瓶	1瓶	25瓶	5瓶	100瓶	50瓶

最小起訂量	1瓶
發(fā)貨地	上海
更新日期	2024-09-14

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產(chǎn)品詳情

中文名稱:環(huán)黃芪醇	英文名稱:Cycloastragenol
CAS:78574-94-4	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.98%	產(chǎn)品類別: 抑制劑
貨號(hào): T5575

Product Introduction

Bioactivity

名稱	Cycloastragenol
描述	Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression
細(xì)胞實(shí)驗(yàn)	Mouse lymphocytes were obtained from spleens and subjected to Con A for 24?h. Herein, the cells were treated with different concentrations of Cyclogalegenol. Cell viability was assayed by MTT. Pretreated by Cyclogalegenol?and stimulated?by Con A,?the expression of CD69 and CD25, Th1/Th2/Th17 cytokines, cell cycle, proliferation and intracellular Ca2+ concentration ([Ca2+]i) were analyzed by flow cytometry[1].
動(dòng)物實(shí)驗(yàn)	Mice were administered Cyclogalegenol?100 mg/kg, or water by oral gavage, or imipramine 15 mg/kg , a currently?used tricyclic antidepressant, by intraperitoneal injection for 7 days as well as 45 min before testing.?The forced swim test was performed as described previously , by placing a mouse in a glass cylinder (height: 30 cm, diameter: 15 cm) filled with water to a depth of 12 cm.?Mice were tested in the cylinder for 6 min. The water was changed before testing another animal.?All test sessions were recorded.?Depression-like behavior was determined by observing the immobility of the mouse, where immobility is defined as when a mouse floats passively in the water with minimal movement to keep its head above the water.?The total period of immobility during the last 4 min of the test session was determined[2].
體外活性	Cyclogalegenol通過抑制淋巴細(xì)胞的激活、增殖和細(xì)胞因子的表達(dá)，具有重要的抗炎活性，其效果可能與減少細(xì)胞內(nèi)Ca2+過載總量有關(guān)[1]。
體內(nèi)活性	通過口服Cyclogalegenol 7天，可緩解實(shí)驗(yàn)小鼠的抑郁樣行為。Cyclogalegenol在人類新生兒角質(zhì)形成細(xì)胞和大鼠神經(jīng)細(xì)胞中刺激端粒酶活性，并誘導(dǎo)CREB激活后繼而引發(fā)tert和bcl2表達(dá)。此外，Cyclogalegenol可能在抑郁癥的治療中具有新穎的作用[2]。
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 98 mg/mL (199.71 mM)
關(guān)鍵字	bone \| cerebral \| Cyclosieversigenin \| loss \| microglia \| Cycloastragenol \| Telomerase \| ameliorated \| neuroinflammation \| Inhibitor \| inhibit \| reperfusion
相關(guān)產(chǎn)品	Bisdemethoxycurcumin \| dBET6 \| 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one \| Costunolide \| CeMMEC1 \| Ceramides Mixture \| (+)-JQ-1 \| Curcumin \| Naphthol AS-E \| ABBV-744
相關(guān)庫	經(jīng)典已知活性庫 \| 植物來源化合物庫 \| 已知活性化合物庫 \| 藥食同源庫 \| 抗衰老化合物庫 \| 抗癌天然產(chǎn)物庫 \| 中藥單體化合物庫 \| 天然產(chǎn)物庫 \| 中藥抗炎分子庫 \| 萜類天然產(chǎn)物庫

關(guān)鍵字：環(huán)黃芪醇|||Cyclogalegenol|||Astramembrangenin

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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