| 中文名 | 鹽酸替莫普利
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| 英文名 | Temocapril hydrochloride
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| 別名 | 鹽酸替莫普利
替莫普利鹽酸鹽
鹽酸替莫普利及中間體
TEMOCAPRIL HYDROCHLORIDE鹽
[(2S,6R)-6-[[(S)-1-(乙氧羰基)-3-苯基丙基]氨基]-5-氧代-2-(2-噻吩基)-1,4-硫氮雜卓-4-基]乙酸鹽酸鹽
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| 英文別名 | CS-622
Acecol
TemocarpileHCL
Temocapril Hcl
Temocarpilhydrochloride
Temocapril hydrochloride
TEMOCAPRIL HYDROCHLORIDE
Temocapril HCl and intermediates
[(2S,6R)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid
(2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Hydrochloride
1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-
1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI)
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| CAS | 110221-44-8
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| EINECS | 1312995-182-4 |
| 化學(xué)式 | C23H28N2O5S2.ClH
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| 分子量 | 513.076 |
| InChI | InChI=1/C23H28N2O5S2/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)/t17-,18-,20-/m0/s1 |
| 密度 | 1.33g/cm3 |
| 熔點 | 196-2000C (dec) |
| 沸點 | 717.4°C at 760 mmHg |
| 比旋光度 | 25D +47.7° (c = 1 in DMF) |
| 閃點 | 387.7°C |
| 蒸汽壓 | 1.34E-21mmHg at 25°C |
| 溶解度 | DMF (微溶) 、DMSO (微溶) 、甲醇 (微溶) |
| 折射率 | 1.628 |
| 存儲條件 | Inert atmosphere,Store in freezer, under -20°C |
| 外觀 | 固體 |
| 顏色 | White to Off-White |
| 體外研究 | Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver. |
| 體內(nèi)研究 | Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney. Animal Model: Male Sprague Dawley rats Dosage: 30 mg/kg Administration: Oral administration, daily, for 4 weeks Result: Suppressed the blood pressure elevation induced by Ang I. |
| 危險品標(biāo)志 | Xi - 刺激性物品
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| 風(fēng)險術(shù)語 | 36/37/38 - 刺激眼睛、呼吸系統(tǒng)和皮膚。
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| 安全術(shù)語 | S26 - 不慎與眼睛接觸后，請立即用大量清水沖洗并征求醫(yī)生意見。
S36 - 穿戴適當(dāng)?shù)姆雷o服。 |