110221-44-8
中文名稱
鹽酸替莫普利
英文名稱
Temocapril hydrochloride
CAS
110221-44-8
分子式
C23H28N2O5S2.HCl
MDL 編號(hào)
MFCD00933433
分子量
513.07
MOL 文件
110221-44-8.mol
更新日期
2024/11/26 10:42:57
110221-44-8 結(jié)構(gòu)式
基本信息
中文別名
[(2S,6R)-6-[[(S)-1-(乙氧羰基)-3-苯基丙基]氨基]-5-氧代-2-(2-噻吩基)-1,4-硫氮雜卓-4-基]乙酸鹽酸鹽替莫普利鹽酸鹽
鹽酸替莫普利
英文別名
TEMOCAPRIL HYDROCHLORIDETemocapril Hcl
TemocarpileHCL
Temocarpilhydrochloride
(2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Hydrochloride
Acecol
CS-622
1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI)
1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-
(+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid hydrochloride
(+)-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid hydrochloride
2-[(2S,6R)-6-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-5-oxo-2-(2-thienyl)-2,5,6,7-tetrahydro-1,4-thiazepine-4(3H)-yl]acetic acid·hydrochloride
所屬類別
生物化工：RAAS 抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)196-2000C (dec)
比旋光度25D +47.7° (c = 1 in DMF)
儲(chǔ)存條件-20°C冷凍
溶解度DMF（微溶）、DMSO（微溶）、甲醇（微溶）
形態(tài)固體
顏色白色至灰白色
CAS 數(shù)據(jù)庫(kù)110221-44-8(CAS DataBase Reference)
鹽酸替莫普利價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-B0384 | 鹽酸替莫普利 Temocapril hydrochloride | 110221-44-8 | 5 mg | 304元 |
| 2024/11/08 | HY-B0384 | 鹽酸替莫普利 Temocapril hydrochloride | 110221-44-8 | 10mM * 1mLin DMSO | 343元 |
| 2024/11/08 | HY-B0384 | 鹽酸替莫普利 Temocapril hydrochloride | 110221-44-8 | 10mg | 480元 |
常見(jiàn)問(wèn)題列表
生物活性
Temocapril HCl (CS-622)是Temocapril的鹽酸鹽形式，是一種長(zhǎng)效的血管緊張素轉(zhuǎn)換酶（ACE）抑制劑，用于治療高血壓。靶點(diǎn)
| Target | Value |
| ACE |
體外研究
Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver.
體內(nèi)研究
Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney.
| Animal Model: | Male Sprague Dawley rats |
| Dosage: | 30 mg/kg |
| Administration: | Oral administration, daily, for 4 weeks |
| Result: | Suppressed the blood pressure elevation induced by Ang I. |