Siglec-3產(chǎn)品信息

英文名稱：Myeloid cell surface antigen CD33

中文名稱：髓系細(xì)胞表面抗原CD33

靶點(diǎn)別稱：CD33、SIGLEC3、gp67

物種：Human / Mouse / Cynomolgus / Rat

屬性：Protein / Beads

標(biāo)記：Biotin-labeled / FITC Labeled / Unconjugated / PE Labeled / AF647 Labeled / APC Labeled

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Siglec-3分子背景

骨髓細(xì)胞表面抗原CD33也稱為SIGLEC3，Siglecs（唾液酸結(jié)合Ig樣凝集素）和GP67，是一種單程I型膜蛋白，屬于免疫球蛋白超家族和SIGLEC（唾液酸結(jié)合Ig樣凝集素）家族。人CD33/Siglec-3 cD編碼一個(gè)364個(gè)氨基酸（aa）的多肽，具有疏水信號(hào)肽，一個(gè)N端Ig樣V型結(jié)構(gòu)域，一個(gè)Ig樣C2型結(jié)構(gòu)域，一個(gè)跨膜區(qū)和一個(gè)細(xì)胞質(zhì)尾部。CD33/Siglec-3通常被認(rèn)為是骨髓特異性的，但它也可以在一些淋巴細(xì)胞上發(fā)現(xiàn)。在免疫應(yīng)答中，CD33/Siglec-3可以通過(guò)其SH2結(jié)構(gòu)域募集細(xì)胞質(zhì)磷酸酶，從而通過(guò)信號(hào)分子的去磷酸化阻斷信號(hào)轉(zhuǎn)導(dǎo)，從而在配體誘導(dǎo)的酪氨酸磷酸化后充當(dāng)抑制性受體.CD33/Siglec-3誘導(dǎo)急性髓系白血病細(xì)胞凋亡。

Siglec-3用戶評(píng)價(jià)