Siglec-8產(chǎn)品信息

英文名稱：Sialic acid-binding Ig-like lectin 8

中文名稱：唾液酸結(jié)合免疫球蛋白樣凝集素-8

靶點(diǎn)別稱：Siglec-8,SAF-2,SIGLEC8,SAF2

物種：Human

屬性：Protein

標(biāo)記：Biotin-labeled/Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

Siglec-8用戶評(píng)價(jià)

Siglec-8分子背景

Siglec-8也稱為SAF2，最初是通過從診斷為特發(fā)性嗜酸性粒細(xì)胞增多綜合征的患者產(chǎn)生的cDNA文庫(kù)中對(duì)EST進(jìn)行CD33同源篩選而鑒定出來的，最初被稱為SAF-2（唾液酸粘附素家族2）。在組織水平上，發(fā)現(xiàn)Siglec-8 mRNA在肺、PBMCs、脾和腎中表達(dá)最高。Siglec-8存在兩種剪接變體。最初表征的形式總共包含431個(gè)氨基酸殘基，隨后是Siglec-8的較長(zhǎng)形式，最初稱為Siglec-8L。這兩種形式的Siglec-8都存在于嗜酸性粒細(xì)胞中，在細(xì)胞外區(qū)域含有一個(gè)具有凝集素活性的V-set結(jié)構(gòu)域和兩個(gè)C2型Ig重復(fù)結(jié)構(gòu)域。