中文名：Tolterodine tartrate
英文名：Tolterodine tartrate
英文別名：PNU-200583E;2-?[(1R)?-?3-?[bis(1-?methylethyl)?amino]?-?1-?phenylpropyl]?-?4-?methyl-phenol?, (2R,?3R)?-?2,?3-?dihydroxybutanedioat?e (1:1)
純度：10mM in DMSO
貨號：T407900
包裝：1ml
Cas號：124937-52-6
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Information
Tolterodine tartrate Tolterodine tartrate (PNU-200583E) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.
In?vitro
Tolterodine has a high affinity and specificity for muscarinic receptors in vitro and it exhibits selectivity for the urinary bladder over salivary glands in vivo. Tolterodine is a new muscarinic receptor antagonist intended for the treatment of urinary urge incontinence and other symptoms related to an overactive bladder. Tolterodine effectively inhibits carbachol-induced contractions of isolated strips of urinary bladder from guinea pigs in a concentration-dependent, competitive manner. Tolterodine binds with high affinity to muscarinic receptors in urinary bladder (Ki 2.7 nM), heart (Ki 1.6 nM), cerebral cortex (Ki 0.75 nM) and parotid gland (Ki 4.8 nM) from guinea pigs and in urinary bladder from humans (Ki 3.3 nM).
In?vivo
Tolterodine (1 mg/kg, i.v.) is significantly more potent in inhibiting acetylcholine-induced urinary bladder contraction than electrically-induced salivation in the anaesthetised cat. Tolterodine administered intravenously increases the mean micturition interval, bladder capacity and micturition volume in normal rats and resiniferatoxin treated rats. Tolterodine (2 nM/kg) significantly increases bladder capacity (BC) in saline vehicle- cerebral infarct rats without increasing residual volume but it has no effects on BC in resiniferatoxin- cerebral infarct rats. Tolterodine tartrate (0.1 and 1.0 mg/kg) significantly decreases the number and amplitude of non-voiding contractions by 38-74% and 29-44%, respectively, and increases bladder capacity by 19-51% in female rats with bladder outlet obstruction.
Cell?Data
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Powder?Purity:≥99%
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關(guān)鍵字： PNU-200583E;2-?[(1R)?-?3-?[bis(1-?methylethyl)?amino]?-?1-?phenylpropyl]?-?4-?methyl-phenol?, (2R,?3R)?-?2,?3-?dihydroxybutanedioat?e (1:1)
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