中文名:3-異丁基-1-甲基黃嘌呤(IBMX)
英文名:3-Isobutyl-1-methylxanthine
中文別名:IBMX|1-甲基-3-異丁基黃嘌呤
英文別名:IBMX|3-Isobutyl-1-methylxanthine|28822-58-4|isobutylmethylxanthine|Methylisobutylxanthine|1-METHYL-3-ISOBUTYLXANTHINE|1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-|3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione|3-isobutyl-1-methylxanthine
純度:10mM in DMSO
貨號(hào):I423008
包裝:1ml
Cas號(hào):28822-58-4
存儲(chǔ)溫度:-80℃儲(chǔ)存
產(chǎn)品介紹:
IBMX is a widely-used non-specific inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors,typically antagonizing the suppressive effects of natural agonists.
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關(guān)鍵字: IBMX;1-甲基-3-異丁基黃嘌呤;IBMX;3-Isobutyl-1-methylxanthine
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