AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. It significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer.

產(chǎn)品名稱: AZD7762

CAS: 860352-01-8

包裝：1g, 5g,10g,100g,1000g

含量：99%

上海化成醫(yī)藥化工有限公司

聯(lián)系人：石先生

電話：13621923966