Butoconazole nitrate (RS 35887) 是一種咪唑類(lèi)抗真菌藥物,對(duì)念珠菌屬有活性,對(duì)白色念珠菌引起的陰道感染有效。Butoconazole nitrate 被認(rèn)為可通過(guò)抑制類(lèi)固醇合成而起其他咪唑衍生物的作用。
Imidazoles generally inhibit the conversion of lanosterol to ergosterol, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell[1].
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