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LY-411575,LY-411575
  • LY-411575,LY-411575

209984-57-6LY-411575

價格 詢價
包裝 1盒
最小起訂量 1盒
發(fā)貨地 上海
更新日期 2024-11-06
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產(chǎn)品詳情

中文名稱:LY-411575英文名稱:LY-411575
CAS:209984-57-6品牌: 一研
保存條件: Store at -20°C產(chǎn)品類別: 抑制劑
Cas : 209984-57-6
2024-11-06 LY-411575 LY-411575 1盒/RMB 一研 Store at -20°C 抑制劑

產(chǎn)品屬性:

產(chǎn)品名稱

規(guī)格

CAS

型號

LY-411575

5mg 10mg 50mg 100mg

209984-57-6

EY-Y0164361

Cas No.209984-57-6

別名

化學(xué)名 (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide

分子式 C26H23F2N3O4

LY-411575.png

分子量 479.48

溶解度 23.85 mg/mL in DMSO, 98.4 mg/mL in EtOH with ultrasonic

儲存條件 Store at -20°C
General tips  For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.
Shipping Condition     Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
LY-411575 is a potent  inhibitor of γ-secretase with IC50 value of 0.078 nM in membrane assay.[1]

γ-Secertase is one of intramenbrane-cleaving aspartyl protease which cleaves many type-I membrane proteins and many of them have important biological functions. γ-Secretase is a multi-subunit protease and it contains presenilin, nicastrin, APH-1(Anterior Pharynx- defective 1) and PEN-2. Presenilin contains Asp258 and Asp385 embedded in the sixth and seventh transmembrane domain and forms the active site. The feature of being a membrane integrated protease complex makes it difficult to be purified as well as studying its mechanism.γ-secretase is responsible for the generation Aβfrom the amyloid precursor protein.γ-Secertase has been considered as an important drug target for Alzheimer's disease.γ-Secertase also is responsible for Notch processing which is related to cancer such as leukemia.[2]

LY-411,575 significantly inhibits theγ-secretase activity in vitro. LY-411,575 inhibits the production of Aβproduction with IC50 value of 0.078 nM in membrane-assay and 0.082 nM in cell-basedγ-secretase assays, respectively. LY-411,575 also affects the Notch pathway by inhibiting Notch S3 cleavage with IC50 value of 0.39 nM.[1] LY-411,575 treatment also significantly inhibited the Notch pathway by inhibiting the γ-secretase activity luciferase activity in primary KS cells. LY-411,575 also induced the apoptosis though Notch pathway inhibition in primary and immortalized Kaposi's sarcoma (KS) tumor cells.[2]

LY-411,575 decreases the levels of brain and plasma Aβ40 and -42 at 10 mg/kg oral doses.[1] LY-411,575 also decreases cortical Aβ40 levels in transgenic CRND8 mice with ED50 0.6 mg/kg. LY-411,575 also induced significantly intestinal goblet cell hyperplasia and thymus atrophy by inhibiting Notch signaling pathway at higher doses in vivo.[3]


關(guān)鍵字: 209984-57-6;C26H23F2N3O4;LY-411575;

公司簡介

上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè),公司自成立以來,秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念,立足生物科技領(lǐng)域,運(yùn)用生物技術(shù)和科研試劑,發(fā)展現(xiàn)代生物科技,為各類大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品,服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。 公司具有對普通貨物、冷藏及冷凍倉庫的存儲、包裝及運(yùn)輸能力。 公司將始終堅持信譽(yù)立業(yè)、以人為本、質(zhì)量保證、誠信服務(wù)的宗旨,不斷拼搏,開拓進(jìn)取,與各界朋友攜手共創(chuàng)美好未來。
成立日期 2014-06-05 (11年) 注冊資本 100
員工人數(shù) 50-100人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 生化試劑,抗體,細(xì)胞培養(yǎng),分子生物學(xué),免疫安全 經(jīng)營模式 工廠,試劑
  • 上海一研生物科技有限公司
VIP 2年
  • 公司成立:11年
  • 注冊資本:100
  • 企業(yè)類型:營業(yè)執(zhí)照
  • 主營產(chǎn)品:、ELISA試劑盒、PCR檢測試劑盒、生化檢測試劑盒、標(biāo)準(zhǔn)品、抗體、細(xì)胞等
  • 公司地址:上海市閔行區(qū)莘福路2號樓
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