Sulbactam
|
|
|
- CAS-Nr.
- 68373-14-8
- Bezeichnung:
- Sulbactam
- Englisch Name:
- Sulbactam
- Synonyma:
- SULBACTAM ACID;sulbactum;CP-45899;penicillanic acid 1,1-dioxide;(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide;Betamaze;SULBACTAM;Shu ba acid;Sulbactam CRS;Sulbactam >
- CBNumber:
- CB1419201
- Summenformel:
- C8H11NO5S
- Molgewicht:
- 233.24
- MOL-Datei:
- 68373-14-8.mol
|
Sulbactam Eigenschaften
- Schmelzpunkt:
- 154-157℃
- alpha
- D20 +251° (c = 0.01 in pH 5.0 buffer)
- Siedepunkt:
- 567.7±50.0 °C(Predicted)
- Dichte
- 1.62±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: ≥18mg/mL
- Aggregatzustand
- lyophilized powder
- pka
- 2.62±0.40(Predicted)
- Farbe
- white to tan
- Optische Aktivit?t
- [α]/D ≥+225°, c = 1 in H2O
- Wasserl?slichkeit
- Soluble in water at 18mg/ml
- Merck
- 14,8889
- Stabilit?t:
- Hygroscopic
- InChIKey
- FKENQMMABCRJMK-RITPCOANSA-N
- CAS Datenbank
- 68373-14-8
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
|
|
| R-S?tze: |
22 |
|
|
| S-S?tze: |
24/25 |
|
|
| WGK Germany |
3 |
|
|
| HS Code |
29349990 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
|
Sulbactam Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Sulbactam is prepared by partial chemical synthesis from
penicillins. The oxidation of the sulfur atom to a sulfone greatly enhances the potency of sulbactam. The
combination of sulbactam and ampicillin (Unasyn) is now clinically popular.
Verwenden
Sulbactam sodium is a semi-synthetic penem antibiotic formed by the oxidation of penicillanic acid to its sulfone and was invented by Barth at Pfizer in 1978. Sulbactam sodium is a weak antibiotic but its action as an irreversible inhibitor of β-lactamase is exploited to block the degradation of other penicillin derivatives. Sulbactam acts as a synergist with cephalosporins and penicillins against Gram positive bacteria and is used commercially in combination with ampicillin.
Antimicrobial activity
Sulbactam has very weak antimicrobial activity against most
bacteria. Its only notable activity is against N. gonorrhoeae,
N. meningitidis and Acinetobacter baumannii.
Clinical Use
Sulbactam is penicillanic acid sulfone or 1,1-dioxopenicillanicacid. This synthetic penicillin derivative is a potent inhibitorof S. aureus β-lactamase as well as many β-lactamaseselaborated by Gram-negative bacilli. Sulbactam has weak intrinsicantibacterial activity but potentiates the activity ofampicillin and carbenicillin against β-lactamase–producingS. aureus and members of the Enterobacteriaceae family. Itdoes not, however, synergize with either carbenicillin or ticarcillinagainst P. aeruginosa strains resistant to these agents.Failure of sulbactam to penetrate the cell envelope is a possibleexplanation for the lack of synergy.
Fixed-dose combinations of ampicillin sodium and sulbactamsodium, marketed under the trade name Unasyn assterile powders for injection, have been approved for use inthe United States. These combinations are recommended forthe treatment of skin, tissue, intra-abdominal, and gynecologicalinfections caused by β-lactamase–producing strainsof S. aureus, E. coli, Klebsiella spp., P. mirabilis, B. fragilis,and Enterobacter and Acinetobacter spp.
Sulbactam Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Sulbactam Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 410)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
|
Nanjing Sinoda Biological Technology Co., Ltd
|
+8613401983379
|
sales@njmcn.cn |
CHINA |
74 |
58 |
|
Hebei Yanxi Chemical Co., Ltd.
|
+8617531190177
|
peter@yan-xi.com |
China |
5857 |
58 |
|
Wuhan Fortuna Chemical Co., Ltd
|
+86-027-59207850
|
info@fortunachem.com |
China |
5975 |
58 |
|
Hebei Chuanghai Biotechnology Co,.LTD
|
+86-13131129325
|
sales1@chuanghaibio.com |
China |
5889 |
58 |
|
Hebei Weibang Biotechnology Co., Ltd
|
+8617732866630
|
bess@weibangbio.com |
China |
18151 |
58 |
|
Henan Fengda Chemical Co., Ltd
|
+86-371-86557731 +86-13613820652
|
info@fdachem.com |
China |
20283 |
58 |
|
airuikechemical co., ltd.
|
+86-18353166132 +86-18353166132
|
sales02@airuikechemical.com |
China |
983 |
58 |
|
Capot Chemical Co.,Ltd.
|
+86-（0）57185586718 +86-13336195806
|
sales@capot.com |
China |
29791 |
60 |
|
Shanghai Daken Advanced Materials Co.,Ltd
|
+86-371-66670886
|
info@dakenam.com |
China |
18751 |
58 |
|
Henan Tianfu Chemical Co.,Ltd.
|
+86-0371-55170693 +86-19937530512
|
info@tianfuchem.com |
China |
21634 |
55 |
68373-14-8(Sulbactam)Verwandte Suche:
- (2S,5R)-3,3-DIMETHYL-4,4,7-TRIOXO-4LAMBDA6-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID
- (2S-CIS)-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3,2,0]HEPTANE-2-CARBOXYLIC ACID 4,4-DIOXIDE
- 3,3-DIMETHYL-4,4,7-TRIOXO-4LAMBDA6-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID
- SULBACTAM
- sulbactam acid (base)
- PENICILLANIC ACID SULFONE
- (2S-cis)-3,3-dimethyl-7-oxy-4-sulph-1-aza dicyclo[3,2,0]heptane-2-carboxylic acid 4,4-dioxide
- SALBACTAM ACID
- Sulbactam free acid
- SULBACTAM FREE ACID((2S-CIS)-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3,2,0]HEPTANE-2-CARBOXYLIC ACID 4,4-DIOXIDE )
- Sulbactam,Penicillanicacidsulfone
- 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, (2S,5R)-
- SULBACTAM(ACIDSODIUM)
- Sulbactam (base and/or unspecified salts)
- (2S-cis)-3，3-Dimethyl-7-oxo-4，4-dioxide-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-4-oxide
- Penicillanicacid 1,1-dioxide：CP-45899：CPL45899-2：Betamaze
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, (2S-cis)-
- Betamaze
- Penicillanic acid S,S-dioxide
- (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylic acid 4,4-dioxid
- (2S,5β)-2β-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4,4-dioxide
- (2S,5β)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid 4,4-dioxide
- Penicillanic acid 4,4-dioxide
- Sulbactam (250 mg) (COLD SHIPMENT REQUIRED)
- Sulbactam (250 mg)H0C3960.976mg/mg(ai)
- SulbactaM - See S8244
- (2S,5R)-3,3-dimethyl-7-oxo-4,4-dioxide-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- Penicillanic acid dioxide
- (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4$l^{6}-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- Sultamicillin Impurity 1（Sultamicillin EP Impurity A）
- Sulbactam/Sulbactam Acid
- Sulbactam, 98%, an irreversible β-lactamase inhibitor
- SULBACTAM(BETAMAZE)
- Sultamicillin EP Impurity A
- Sulbactam for peak identification CRS
- Sulbactam CRS
- Sulbactam >
- Sulbactam USP/EP/BP
- Sulbactam (CP 45899 and Betamaze)
- (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide[Sulbactam
- Sulbactam (COLD SHIPMENT REQUIRED) (1623670)
- SULBACTAM ACID
- penicillanic acid 1,1-dioxide
- CP-45899
- sulbactum
- Shu ba acid
- (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
- 2H5]-Sulbactam
- methylene (2S,5R,6R)-6-[[(2R)-[[[[(2R)-aminophenylacetyl]amino][(4S)-4-[[[[[(2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]oxy]methoxy]carbonyl]-5,5-dimethylthiazolidin-2-yl]acetyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate (2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate (sultamicillin dimer)
- N-[[(2RS)-1-éthylpyrrolidin-2-yl]méthyl]-2-hydroxy-5-sulfamoylbenzamide
- Sultamicillin Impurity A
- Sultamicillin Tosilate Dihydrate EP Impurity A
- Sultamicillin Tosilate Dihydrate Impurity A
- C16986600 Sulbactam
- Rimsulfuron Impurity 4(Sulfosulfuron)
- 68373-14-8
- 6837-14-8
- 73-14-8
