Tazobactam acid
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Tazobactam acid Eigenschaften
- Schmelzpunkt:
- 115-145℃
- Siedepunkt:
- 77℃
- Dichte
- 1.92±0.1 g/cm3(Predicted)
- RTECS-Nr.
- XI0191400
- Flammpunkt:
- >110°(230°F)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)
- Aggregatzustand
- Solid
- pka
- 2.33±0.40(Predicted)
- Farbe
- White to Off-White
- Wasserl?slichkeit
- Soluble in water
- Stabilit?t:
- Light Sensitive
- InChI
- InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1
- InChIKey
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N
- SMILES
- N12[C@@]([H])(CC1=O)S(=O)(=O)[C@@](C)(CN1C=CN=N1)[C@@H]2C(O)=O
- CAS Datenbank
- 89786-04-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
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Tazobactam acid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Tazobactam often is coadministered with piperacillin because of tazobactam's ability to inhibit β-lactamases. T azobactam, like other β-lactamase inhibitors, has little or no antibacterial activity. This effect is analogous to that of clavulanic acid and sulbactam.Chemische Eigenschaften
White or off-white powderVerwenden
b-lactamase inhibitorDefinition
ChEBI: A member of the class of penicillanic acids that is sulbactam in which one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicat d intra-abdominal infections and complicated urinary tract infections.Antimicrobial activity
Tazobactam exhibits little useful antimicrobial activity, although weak activity against Acinetobacter spp. and Borrelia burgdorferi has been reported.Mechanism of action
Tazobactam functions as an irreversible inhibitor by covalently binding to β-lactamases, and prevents the enzyme hydrolysis of ceftolozane, thereby enhancing its activity against resistant ESBL-producing pathogens, along with expanding coverage to include anaerobes (e.g., Bacteroides spp.)Clinical Use
Tazobactam is a penicillanic acid sulfone that is similar instructure to sulbactam. It is a more potent β-lactamaseinhibitor than sulbactam and has a slightly broader spectrumof activity than clavulanic acid. It has very weak antibacterialactivity. Tazobactam is available in fixed-dose, injectablecombinations with piperacillin, a broad-spectrum penicillinconsisting of an 8:1 ratio of piperacillin sodium to tazobactamsodium by weight and marketed under the trade name Zosyn.The pharmacokinetics of the two drugs are very similar. Bothhave short half-lives (t1/2 ~1 hour), are minimally proteinbound, experience very little metabolism, and are excreted inactive forms in the urine in high concentrations.Approved indications for the piperacillin–tazobactamcombination include the treatment of appendicitis, postpartumendometritis, and pelvic inflammatory disease caused byβ-lactamase–producing E. coli and Bacteroides spp., skin andskin structure infections caused by β-lactamase–producingS. aureus, and pneumonia caused by β-lactamase–producingstrains of H. influenzae.
Tazobactam acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Sulbactam
Natriumazid
Ethanol
Kaliumbromid
Kaliumiodid
Tazobactam sodium
Peroxyessigs?ure ...%
3-Amino-5-mercapto-1,2,4-triazole
Kaliumpermanganat
Vinylacetat
phenylhydrazone
Ammoniumacetat
Celite
Downstream Produkte
Tazobactam acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 358)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hpets Biotech Company (Chongqing) Co.,ltd | +8613340353813 |
info@hanpets.com | China | 26 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8615531157085 |
abby@weibangbio.com | China | 8810 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12835 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 |
FandaChem@Gmail.com | China | 9087 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2986 | 55 |
89786-04-9()Verwandte Suche:
Zitronensure
1,2,4-Triazol
Tazobactam sodium
5-Methyl-1H-benzotriazol
ACETIC ACID
Acetonitril
Methyl-1H-benzotriazol
Paraquat-dichlorid
Methyl-4-hydroxybenzoat
Basic Violet 1
Benzotriazol (in atembarer Form)
Glycin
Folsure
Methanol
Kresoxim-methyl
Methylacetat
Methylacrylat
ASCORBICACID
- 4,4-dioxide,(2s-(2-alpha,3-beta,5-alpha))--triazol-1-ylmethyl)
- cl298741
- ytr83oh
- tazobactam acid
- TAZOBACTAN ACID
- (2S,3S,5R)-3-METHYL-4,4,7-TRIOXO-3-[1,2,3]TRIAZOL-1-YLMETHYL-4LAMBDA6-THIA-1-AZA-BICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID
- Tazobactam, Free acid
- 2b-[(1,2,3-triazol-1-yl)methyl]-2a-methylpenam-3a-carboxylic acid 1,1-dioxide
- CL-298741:YTR-830
- YTR-830H
- (2s,3s,5r)-3-methyl-4,4,7-trioxo-3-(1h-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- Tazobactam,Tazobactanacid
- Tazobactum (Free acid)
- [2S-(2α,3β,5α)]-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
- (2S,3S,5R)-2-Carboxy-3-methyl-3-[(1H-1,2,3-triazol-1-yl)methyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4,4-dioxide
- Tazobactam (200 mg)
- (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylMethyl)-4$l^{6}-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- Tazobactam acid (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- [2S-(2α,3β,5α)]-3-Methyl-7-oxo-3-(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptan-2-carbonsure-4,4-dioxid
- (2S,3S,5R)-3-METHYL-7-OXO-3-(1H-1,2,3-TRIAZOLE-1-YLMETHYL)-4- THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID 4,4-DIOXIDE
- Tarobactam acid
- Tazobactamum
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)-
- (2S,3S,5R)-3-((1H-1,2,3-Triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
- Tazobactam acid USP/EP/BP
- Tazobactam (CL-298741
- Tazobactam acidQ: What is Tazobactam acid Q: What is the CAS Number of Tazobactam acid Q: What is the storage condition of Tazobactam acid Q: What are the applications of Tazobactam acid
- Tazobactam (1643383)
- 5-benzodioxepin-3(4H)-one
- 7-Methyl-2H-1
- TAZOBACTAM
- (2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
- He (the temple
- (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- Tazobactamum|||Tazobactam acid|||YTR-830H|||CL-298741
- 89786-04-9
- C10H12N4O5S
- TAZOCIN
- Amino Acid Derivatives
- Peptide Synthesis/Antibiotics
- pharmaceutical