中文名稱

拉波普蘭特; （3R）-4-[[（4-氯苯基）甲基]-7-氟-1,2,3,4-四氫-5-（甲基磺酰基）-環(huán)戊[b]吲哚-3-乙酸

英文名字

Laropiprant; (3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-cyclopent[b]indole-3-acetic acid

供應(yīng)商

開曼生物

產(chǎn)品貨號

10009835-25

產(chǎn)品報價

￥7284.2/25mg

產(chǎn)品說明書

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購買方式

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產(chǎn)品新聞

背景資料

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} Two seven-transmembrane G protein-coupled receptors for PGD2, designated DP1 and CRTH2/DP2, have been identified.{15538} Activation of the DP1 receptor leads to an increase of intracellular cAMP levels. However, activation of DP2 results in mobilization of intracellular Ca2+ and an apparent decrease in intracellular cAMP.{11488} MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 μM for the DP1 and DP2 receptors, respectively.{14713} It inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively.{14713} In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion.{14713} At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a mouse model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.{15245}

產(chǎn)品描述

A potent, selective DP1 receptor antagonist that binds DP1 and DP2 receptors with Ki values of 0.57 nM and 0.75 μM, respectively

保存建議

建議您在收到開曼生物品牌的MK 0524 (25 mg)產(chǎn)品后置于-20度保存，產(chǎn)品有效期為730天.

其他

開曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類花生酸類物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體.作為開曼生物在中國的區(qū)域總代理，艾美捷科技有限公司將為中國客戶提供最全面的開曼生物產(chǎn)品以及客戶訂制化服務(wù).