Trovafloxacin mesylate NEW
| Price | $31 | $72 | $122 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-09 |
Product Details
| Product Name: Trovafloxacin mesylate | CAS No.: 147059-75-4 |
| Purity: 99.12% | Supply Ability: 10g |
| Release date: 2024/11/09 |
Product Introduction
Bioactivity
| 名稱 | Trovafloxacin mesylate |
| 描述 | Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the pannexin 1 channel (PANX1, IC50 = 4 μM). |
| 體外活性 | Trovafloxacin mesylate is an inhibitor of TO-PRO-3 uptake by apoptotic cells and inhibits ATP release from apoptotic cells. Trovafloxacin mesylate does not inhibit caspase 3/7 activation, or caspase-mediated PANX1 cleavage during apoptosis[1]. Trovafloxacin mesylate is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL reported for more than 700 isolates. The MICs of Trovafloxacin mesylate at which 90% of isolates are inhibited for 55 isolates of pneumococci is 0.125 μg/mL[2]. Trovafloxacin mesylate prolongs TNF-induced activation of MAPKs and IKKα/β activation in HepG2 cells. Trovafloxacin mesylate (20 μM; 24 hours) and tumor necrosis factor (TNF; 4 ng/mL) incubation induces apoptosis and increases leakage of lactate dehydrogenase (LDH). Trovafloxacin mesylate (20 μM; 24 hours) and TNF (4 ng/mL) incubation increases expression of early NF-κB-related factors A20 and IκBα[3]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 120 mg/mL (234.16 mM), Sonication and heating to 60℃ are recommended. H2O : 18 mg/mL (35.12 mM), Sonication is recommended. |
| 關(guān)鍵字 | topoisomerase-IV | TNF | gyrase | Bacterial | hepatotoxicity | LPS | Trovafloxacin | broad-spectrum | Trovafloxacin mesylate | Antibiotic | DNA | Inhibitor | PANX1 | Topoisomerase | pneumococci | inhibit | pro-inflammatory | NF-κB | Trovafloxacin Mesylate |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Dehydroacetic acid sodium | 5-Fluorouracil | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Guanidine hydrochloride | Metronidazole | Doxycycline | Thymidine | Dimethyl sulfoxide |
| 相關(guān)庫 | DNA 損傷和修復(fù)分子庫 | 經(jīng)典已知活性庫 | EMA 上市藥物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | FDA 上市藥物庫 | 抗癌上市藥物庫 | 口服活性化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 細(xì)胞周期化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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