呋喃洛芬
中文名稱 | 呋喃洛芬 |
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中文同義詞 | 呋喃洛芬;化合物 T16715 |
英文名稱 | furaprofen |
英文同義詞 | furaprofen;2-(3-phenyl-1-benzofuran-7-yl)propanoic acid;7-Benzofuranacetic acid, α-methyl-3-phenyl-;furaprofen USP/EP/BP;Furaprofen [USAN:INN] |
CAS號 | 67700-30-5 |
分子式 | C17H14O3 |
分子量 | 266.295 |
EINECS號 | 2669196 |
相關(guān)類別 | |
Mol文件 | 67700-30-5.mol |
結(jié)構(gòu)式 |
呋喃洛芬 性質(zhì)
沸點(diǎn) | 449.4±33.0 °C(Predicted) |
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密度 | 1.230±0.06 g/cm3(Predicted) |
儲存條件 | Store at -20°C |
溶解度 | 溶于二甲基亞砜 |
形態(tài) | 固體 |
酸度系數(shù)(pKa) | 4?+-.0.30(Predicted) |
顏色 | 白色至淺黃色 |
EC50: ~30 nM (HCV genotype 1a and 1b replicons), ~1000 nM (HCV genotype 2a replicon)
Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC 50 ) of Furaprofen is found to range from 2 μM to ≥10 μM, depending on the cell type and proliferation status.
安全信息
更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
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2024/11/08 | HY-U00213 | Furaprofen | 1 mg | 3400元 | |
2024/08/19 | HY-U00213 | 呋喃洛芬 Furaprofen | 67700-30-5 | 5mg | 8500元 |