呋喃洛芬
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- CAS號:
- 67700-30-5
- 英文名:
- furaprofen
- 英文別名:
- furaprofen;furaprofen USP/EP/BP;Furaprofen [USAN:INN];7-Benzofuranacetic acid, α-methyl-3-phenyl-;2-(3-phenyl-1-benzofuran-7-yl)propanoic acid
- 中文名:
- 呋喃洛芬
- 中文別名:
- 呋喃洛芬;化合物 T16715
- CBNumber:
- CB8908528
- 分子式:
- C17H14O3
- 分子量:
- 266.295
- MOL File:
- 67700-30-5.mol
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呋喃洛芬化學(xué)性質(zhì)
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沸點(diǎn):
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449.4±33.0 °C(Predicted)
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密度:
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1.230±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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4?+-.0.30(Predicted)
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顏色:
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White to light yellow
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呋喃洛芬性質(zhì)、用途與生產(chǎn)工藝
Furaprofen (R803) 是一種有效的 HCV 復(fù)制抑制劑。作用于 HCV 基因型 1a 和 1b 復(fù)制子時(shí) EC50 約為 30 nM,作用于基因型 2a 復(fù)制子時(shí) EC50 約為 1000 nM。
EC50: ~30 nM (HCV genotype 1a and 1b replicons), ~1000 nM (HCV genotype 2a replicon)
Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC
50
) of Furaprofen is found to range from 2 μM to ≥10 μM, depending on the cell type and proliferation status.
呋喃洛芬
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更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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2024/11/08 | HY-U00213 | Furaprofen | | 1 mg | 3400元 |
2024/08/19 | HY-U00213 | 呋喃洛芬 Furaprofen | 67700-30-5 | 5mg | 8500元 |
67700-30-5, 呋喃洛芬 相關(guān)搜索:
- 抑制劑
- 化合物 T16715
- 呋喃洛芬
- 67700-30-5
- Furaprofen [USAN:INN]
- furaprofen USP/EP/BP
- 7-Benzofuranacetic acid, α-methyl-3-phenyl-
- 2-(3-phenyl-1-benzofuran-7-yl)propanoic acid
- furaprofen