卡立泊來德
| 中文名稱 | 卡立泊來德 |
|---|---|
| 中文同義詞 | 卡立泊來德;N-(氨基亞氨基甲基)-4-(1-甲基乙基)-3-(甲磺?；?苯甲酰胺;N-(二氨基亞甲基)-4-異丙基-3-(甲磺?；?苯甲酰胺;CARIPORIDE,NHE1抑制劑;卡立泊來德,10 MM DMSO 溶液 |
| 英文名稱 | CARIPORIDE |
| 英文同義詞 | CARIPORIDE;N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide;N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide;N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide;BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-;Cariporide (HOE-642);CS-1692;Sodium/hydrogen Exchanger,Na+/H+ Exchanger (NHE),inhibit,Sodium-hydrogen Exchanger,HOE642,Inhibitor,Cariporide,HOE 642 |
| CAS號(hào) | 159138-80-4 |
| 分子式 | C12H17N3O3S |
| 分子量 | 283.35 |
| EINECS號(hào) | 1592732-453-0 |
| 相關(guān)類別 | 小分子抑制劑;小分子抑制劑，天然產(chǎn)物;合成材料中間體;Inhibitors |
| Mol文件 | 159138-80-4.mol |
| 結(jié)構(gòu)式 |  |
卡立泊來德 性質(zhì)
| 熔點(diǎn) | 90-94° (dec) |
|---|---|
| 密度 | 1.34 |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 不溶于水； DMSO 中≥12.05 mg/mL；溫和加熱和超聲波下，乙醇中≥2.675 mg/mL |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| Target | Value |
|
NHE1
(CHO-K1 cells) | 30 nM |
Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na + and Ca 2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H 2+ O 2+ . Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca 2+ in cardiac myocytes through inhibition of Na + /H + exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
Intravenous administration of cariporide significantly decreases brain Na + uptake and reduces cerebral edema, brain swelling, and infarct volume.
安全信息
| RTECS號(hào) | CV2310560 |
|---|
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-19693 | 卡立泊來德 Cariporide | 159138-80-4 | 1 mg | 250元 |
| 2025/02/08 | HY-19693 | 卡立泊來德 Cariporide | 159138-80-4 | 5mg | 550元 |