BRICICLIB
| 中文名稱 | BRICICLIB |
|---|---|
| 中文同義詞 | 布瑞西利, >98%;布瑞西利;BRICICLIB (SYNONYMS: ON 014185);化合物BRICICLIB;(E)-2-甲氧基-5-((((2,4,6-三甲氧基苯乙烯基)磺酰基)甲基)苯基 磷酸二氫酯 |
| 英文名稱 | Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) |
| 英文同義詞 | Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate);Briciclib,ON-014185;ON-014185;(E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate;2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate;Briciclib(ON 013105,ON 014185);Briciclib, >98%;ON013105;ON014185;ON-013105;ON-014185 |
| CAS號 | 865783-99-9 |
| 分子式 | C19H23O10PS |
| 分子量 | 474.42 |
| EINECS號 | |
| 相關(guān)類別 | 小分子抑制劑;API |
| Mol文件 | 865783-99-9.mol |
| 結(jié)構(gòu)式 |  |
BRICICLIB 性質(zhì)
| 儲存條件 | Sealed in dry,Room Temperature |
|---|---|
| 溶解度 | DMF：30mg/mL；二甲基亞砜：30mg/mL |
| 形態(tài) | 結(jié)晶固體 |
| 顏色 | 白色至米白色 |
Briciclib (ON-014185)是ON-013100的水溶性衍生物。ON-013100是一種可與eIF4E結(jié)合并抑制其活性的小分子化合物。
eIF4E
Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI 50 s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | S6533 | BRICICLIB Briciclib | 865783-99-9 | 2mg | 795.41元 |
| 2023/03/20 | XW86578399903 | 布瑞西利 | 865783-99-9 | 5MG | 240元 |