莫匹羅星鈣(二水合物)
| 中文名稱 | 莫匹羅星鈣(二水合物) |
|---|---|
| 中文同義詞 | 莫匹羅星鈣;莫匹羅星鈣(二水合物);莫匹羅星鈣 USP標(biāo)準(zhǔn)品;莫匹羅星鈣微粉;優(yōu)選]MUPIROCIN CALCIUM HYDRATE;莫匹羅星鈣|||MUPIROCIN CALCIUM |
| 英文名稱 | MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD |
| 英文同義詞 | MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD;Calcium mupirocin dihydrate;L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, calcium salt (2:1), dihydrate, [2E,8[2S,3S(1S,2S)]]- (9CI);mupirocin calcium hydrate;Calcium 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate dihydrate;Mupirocin calcium dihydrate;Mupirocin Calcium (200 mg);5,9-ANHYDRO-2,3,4,8-TETRADEOXY-8-[[3-(2-HYDROXY-1-METHYLPROPYL)OXIRANYL]METHYL]-3-METHYL-[2E,8[2S,3S(1S,2S)]]-L-TALONONO |
| CAS號 | 115074-43-6 |
| 分子式 | C52H86CaO18.2H2O |
| 分子量 | 1075.34 |
| EINECS號 | 200-158-5 |
| 相關(guān)類別 | 醫(yī)藥原料 抗生素;其他化工產(chǎn)品;其他原料;醫(yī)藥原料;醫(yī)藥化工類;原料藥;醫(yī)藥原料藥-科研原料;其他原料;日用化學(xué)品;化學(xué)試劑;API |
| Mol文件 | 115074-43-6.mol |
| 結(jié)構(gòu)式 |  |
莫匹羅星鈣(二水合物) 性質(zhì)
| 熔點(diǎn) | 132-139 °C |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | 極微溶于水，微溶于無水乙醇和二氯甲烷。 |
| 形態(tài) | 固體 |
| 顏色 | 白色至類白色 |
| 水溶解性 | Water: 6 mg/mL (5.58 mM) |
莫匹羅星鈣(二水合物)主要用作抗生素類醫(yī)藥原料。Mupirocin Calcium (Pseudomonic acid A)是mupirocin的鈣鹽形式。Mupirocin是一種天然的巴豆酸衍生物，提取自熒光假單胞菌，抑制細(xì)菌蛋白質(zhì)合成，被用作一種抗生素。
Mupirocin Calcium Salt shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin Calcium Salt is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum.
Mupirocin Calcium Salt is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A.
安全信息
| WGK Germany | 3 |
|---|---|
| 海關(guān)編碼 | 2941906000 |
| 毒性 | mouse,LD50,intravenous,1638mg/kg (1638mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996. |