SOBETIROME
| 中文名稱 | SOBETIROME |
|---|---|
| 中文同義詞 | 化合物SOBETIROME;2-(4-(4-羥基-3-異丙基芐基)-3,5-二甲基苯氧基)乙酸;索貝羅姆 |
| 英文名稱 | QRX 431 |
| 英文同義詞 | Anti-solute carrier family 25 (mitochondrial carrier: glutamate), member 22;[4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid;QRX 431;GC-1;SobetiroMe;[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]acetic acid;GC 1 (pharmaceutical);2-(4-(4-Hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid |
| CAS號 | 211110-63-3 |
| 分子式 | C20H24O4 |
| 分子量 | 328.4 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 211110-63-3.mol |
| 結(jié)構(gòu)式 |  |
SOBETIROME 性質(zhì)
| 熔點 | 122 - 124°C |
|---|---|
| 沸點 | 510.2±45.0 °C(Predicted) |
| 密度 | 1.152±0.06 g/cm3(Predicted) |
| 儲存條件 | -20°C |
| 溶解度 | DMSO：可溶10mg/mL，澄清 |
| 酸度系數(shù)(pKa) | 3.22±0.10(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| InChIKey | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
Sobetirome (GC-1) 是一種甲狀腺激素受體 β (TRβ) 激動劑，Sobetirome可選擇性結(jié)合到TRβ-1，EC50 為 0.16 μM。
EC50: 0.16 μM (TRβ-1), 0.58 μM (TRα-1)
Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20% (1.3 g).
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-14823 | Sobetirome | 1 mg | 500元 | |
| 2024/08/19 | HY-14823 | SOBETIROME Sobetirome | 211110-63-3 | 5mg | 1100元 |