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ChemicalBook >> CAS DataBase List >> TG4-155

TG4-155

TG4-155 price.
  • $62 - $5328
  • Product name: TG4-155
  • CAS: 1164462-05-8
  • MF: C23H26N2O4
  • MW: 394.46
  • EINECS:
  • MDL Number:MFCD03829939
  • Synonyms:TG4-155;(E)-N-(2-(2-Methyl-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide;TG4-155; TG-4-155; TG 4-155; TG4155; TG-4155; TG 4155;(2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide;2-Propenamide, N-[2-(2-methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-;inhibit,TG4-155,TG-4-155,TG4155,TG4 155,Prostaglandin Receptor,Inhibitor
23 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Matrix Scientific
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAK Scientific
  • Product numberSYN5120
  • Product descriptionTG4-155
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberBRS0009230
  • Product descriptionTG4-155 95.00%
  • Packaging5MG
  • Price$459.22
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5279
  • Product descriptionTG4-155
  • Packaging5mg
  • Price$103
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5279
  • Product descriptionTG4-155
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573466
  • Product descriptionTG4-155 >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573466
  • Product descriptionTG4-155 >98%
  • Packaging250mg
  • Price$1431.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573466
  • Product descriptionTG4-155 >98%
  • Packaging1g
  • Price$2839
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17639
  • Product descriptionTG4-155 ≥98%
  • Packaging5mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17639
  • Product descriptionTG4-155 ≥98%
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17639
  • Product descriptionTG4-155
  • Packaging25mg
  • Price$239
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17639
  • Product descriptionTG4-155
  • Packaging50mg
  • Price$448
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0014805
  • Product descriptionTG4-155 99.12%
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0014805
  • Product descriptionTG4-155 99.12%
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0014805
  • Product descriptionTG4-155 99.12%
  • Packaging25mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0014805
  • Product descriptionTG4-155 99.12%
  • Packaging50mg
  • Price$490
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0014805
  • Product descriptionTG4-155 99.12%
  • Packaging100mg
  • Price$880
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5120 TG4-155 10mg $130 2021-12-16 Buy
American Custom Chemicals Corporation BRS0009230 TG4-155 95.00% 5MG $459.22 2021-12-16 Buy
ApexBio Technology C5279 TG4-155 5mg $103 2021-12-16 Buy
ApexBio Technology C5279 TG4-155 10mg $180 2021-12-16 Buy
Biorbyt Ltd orb573466 TG4-155 >98% 100mg $838.1 2021-12-16 Buy
Biorbyt Ltd orb573466 TG4-155 >98% 250mg $1431.4 2021-12-16 Buy
Biorbyt Ltd orb573466 TG4-155 >98% 1g $2839 2021-12-16 Buy
Cayman Chemical 17639 TG4-155 ≥98% 5mg $62 2024-03-01 Buy
Cayman Chemical 17639 TG4-155 ≥98% 10mg $109 2024-03-01 Buy
Cayman Chemical 17639 TG4-155 25mg $239 2024-03-01 Buy
Cayman Chemical 17639 TG4-155 50mg $448 2024-03-01 Buy
ChemScene CS-0014805 TG4-155 99.12% 5mg $80 2021-12-16 Buy
ChemScene CS-0014805 TG4-155 99.12% 10mg $130 2021-12-16 Buy
ChemScene CS-0014805 TG4-155 99.12% 25mg $280 2021-12-16 Buy
ChemScene CS-0014805 TG4-155 99.12% 50mg $490 2021-12-16 Buy
ChemScene CS-0014805 TG4-155 99.12% 100mg $880 2021-12-16 Buy

Properties

Boiling point :641.3±55.0 °C(Predicted)
Density :1.14±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
pka :14.04±0.46(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Prostaglandin E2 (PGE2) evokes distinct responses through four different ‘E prostanoid’ (EP) receptors. EP2 is a G protein-coupled receptor that has diverse roles, including those in cancer, inflammation, and neuroprotection. TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 μM) and a panel of other receptors and channels. It blocks the induced expression of inflammatory markers in microglial cells treated with the selective EP2 agonist butaprost alone or with LPS and IFNγ. TG4-155 significantly reduces neurodegeneration in a mouse model of status epilepticus, induced by pilocarpine . It inhibits proliferation, invasion, and inflammatory cytokine expression in cancer cells treated with butaprost.

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