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ChemicalBook >> CAS DataBase List >> Streptonigrin

Streptonigrin

Streptonigrin price.
  • $118 - $700
  • Product name: Streptonigrin
  • CAS: 3930-19-6
  • MF: C25H22N4O8
  • MW: 506.46
  • EINECS:223-501-8
  • MDL Number:MFCD00063401
  • Synonyms:rufocromomycin;streptonigrin from streptomyces flocculus;Streptonigrin, Streptomyces flocculus;Bruneomycin, Nigrin;5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;Abbott Crystalline antibiotic;AO 50165L302
9 prices
Selected condition：
Brand
  • Biosynth Carbosynth
  • Cayman Chemical
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 2mg
  • 2.5mg
  • 5mg
  • ManufacturerBiosynth Carbosynth
  • Product numberFA43266
  • Product description5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid
  • Packaging5mg
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA43266
  • Product description5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid
  • Packaging2mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA43266
  • Product description5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid
  • Packaging1mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27952
  • Product descriptionStreptonigrin
  • Packaging1mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27952
  • Product descriptionStreptonigrin
  • Packaging5mg
  • Price$529
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberS1014
  • Product descriptionStreptonigrin from Streptomyces flocculus ≥98%
  • Packaging5mg
  • Price$432
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberS1014
  • Product descriptionStreptonigrin from Streptomyces flocculus ≥98%
  • Packaging1mg
  • Price$119
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberS687555
  • Product descriptionStreptonigrin from Streptomyces flocculus
  • Packaging2.5mg
  • Price$395
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product numberS7975-09
  • Product descriptionStreptonigrin
  • Packaging1mg
  • Price$490
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Biosynth Carbosynth FA43266 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid 5mg $700 2021-12-16 Buy
Biosynth Carbosynth FA43266 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid 2mg $420 2021-12-16 Buy
Biosynth Carbosynth FA43266 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid 1mg $250 2021-12-16 Buy
Cayman Chemical 27952 Streptonigrin 1mg $118 2024-03-01 Buy
Cayman Chemical 27952 Streptonigrin 5mg $529 2024-03-01 Buy
Sigma-Aldrich S1014 Streptonigrin from Streptomyces flocculus ≥98% 5mg $432 2024-03-01 Buy
Sigma-Aldrich S1014 Streptonigrin from Streptomyces flocculus ≥98% 1mg $119 2024-03-01 Buy
TRC S687555 Streptonigrin from Streptomyces flocculus 2.5mg $395 2021-12-16 Buy
Usbiological S7975-09 Streptonigrin 1mg $490 2021-12-16 Buy

Properties

Melting point :301-303℃
Boiling point :595.12°C (rough estimate)
Density :1.4130 (rough estimate)
refractive index :1.6000 (estimate)
storage temp. :2-8°C
solubility :Chloroform:Methanol (1:1): 2 mg/ml
form :A solid
pka :6.2-6.4 (1:1 aq dioxane)
color :Light brown to brown
Merck :13,8907
BRN :599390

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Streptonigrin is a phenylpyridylquinoline originally isolated from S. flocculus with diverse biological activities. Streptonigrin (2.5-12.5 μM) induces DNA cleavage by calf thymus topoisomerase II in a concentration-dependent manner. It induces phage production in S. typhimurium when used at concentrations ranging from 1 to 10 μg/ml. Streptonigrin (10 μg/ml) inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria. Streptonigrin is bactericidal against E. coli in an iron-dependent manner, an effect that is blocked by the iron chelators deferoxamine and orthophenanthroline. Streptonigrin (40 nM) is cytotoxic to human HT-29 colon carcinoma cells but not to BE colon carcinoma cells in which NAD(P)H:quinone oxidoreductase is not expressed. Streptonigrin (0.001-0.1 μg/ml) inhibits mitosis and induces chromatin breaks in human leukocytes in a concentration-dependent manner. In vivo, streptonigrin (0.05 mg/kg, i.p.) increases the mean survival time in rats infected with Rauscher virus.

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