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Postion:Product Catalog >API>Antineoplastic agents>Antibiotics anticancer drugs> BRUNEOMYCIN
	BRUNEOMYCIN
  • 	BRUNEOMYCIN

BRUNEOMYCIN

Price $1
Package 1kg
Min. Order: 1kg
Supply Ability: 100KG
Update Time: 2019-07-06

Product Details

Product Name: BRUNEOMYCIN CAS No.: 3930-19-6
Min. Order: 1kg Purity: 99%
Supply Ability: 100KG Release date: 2019/07/06

AD68

BRUNEOMYCIN Basic information
Product Name: BRUNEOMYCIN
Synonyms: rufocromomycin;streptonigrin from streptomyces flocculus;Streptonigrin, Streptomyces flocculus;Bruneomycin, Nigrin;5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;BruneoMycin, Nigrin, RufocroMoMycin, Valacidin, RP 5278;5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;Abbott Crystalline antibiotic
CAS: 3930-19-6
MF: C25H22N4O8
MW: 506.46
EINECS: 223-501-8
Product Categories:  
Mol File: 3930-19-6.mol
Article illustration
 
BRUNEOMYCIN Chemical Properties
Melting point  301-303℃
Boiling point  595.12°C (rough estimate)
density  1.4130 (rough estimate)
refractive index  1.6000 (estimate)
storage temp.  2-8°C
pka 6.2-6.4 (1:1 aq dioxane)
Merck  13,8907
 
Safety Information
Hazard Codes  T+
Risk Statements  28
Safety Statements  53-28-36/37/39-45
RIDADR  UN 3462 6.1/PG 1
WGK Germany  3
RTECS  TJ7350000
10-18
HazardClass  6.1(a)
PackingGroup  II
MSDS Information
Provider Language
SigmaAldrich English
 
BRUNEOMYCIN Usage And Synthesis
Chemical Properties Brown to red solid. Soluble in polar solvents and alkaline solutions; insoluble in most nonpolar solvents and acid solutions.
Uses Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumour cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1).
Uses Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumor cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1).
Definition ChEBI: Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Brand name Nigrin (Pfizer).
Purification Methods Streptonigrin is purified by TLC on pH 7-buffered silica gel plates (made from a slurry of Silica Gel 60 and 400mL of 0.05M phosphate buffer pH 7.0) and eluted with 5% MeOH/CHCl3. Material from the extracted band recrystallises from Me2CO or dioxane as almost black plates or needles. It is soluble in pyridine, Me2NCHO, aqueous NaHCO3 (some dec), and slightly soluble in MeOH, EtOH, EtOAc and H2O. It has UV max 248, 375-380nm ( 38,400 and 17,400). [Weinreb et al. J Am Chem Soc 104 536 1982, Rao et al. J Am Chem Soc 85 2532 1963.] Itis antineoplastic and causes severe bone marrow depression [Wilson et al. Antibiot Chemother 11 147 1961].
 
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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