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ChemicalBook >> CAS DataBase List >> RVX-208

RVX-208

RVX-208 price.
  • $44 - $1423
  • Product name: RVX-208
  • CAS: 1044870-39-4
  • MF: C20H22N2O5
  • MW: 370.4
  • EINECS:
  • MDL Number:MFCD18633270
  • Synonyms:2-(4-(2-hydroxyethoxy)-3,5-diMethylphenyl)-5,7-diMethoxyquinazolin-4(3H)-one;RVX-000222;4(3H)-Quinazolinone, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-;2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone RVX-208;RVX-208;Apabetalone;Apabetalone-RVX-208;RVX-208(RVX 000222)
28 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • BroadPharm
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberZ3839
  • Product descriptionRVX-208
  • Packaging50mg
  • Price$522.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0387744
  • Product description2-(4-(2-HYDROXYETHOXY)-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE 95.00%
  • Packaging5MG
  • Price$497.28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1499
  • Product descriptionRVX-208
  • Packaging5mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545916
  • Product descriptionRVX-208 >98%
  • Packaging25mg
  • Price$508.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545916
  • Product descriptionRVX-208 >98%
  • Packaging5mg
  • Price$187
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFR137715
  • Product descriptionRVX 208
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFR137715
  • Product descriptionRVX 208
  • Packaging50mg
  • Price$437.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-23380
  • Product descriptionRVX-208 98%
  • Packaging10mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-23380
  • Product descriptionRVX-208 98%
  • Packaging25mg
  • Price$490
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-23380
  • Product descriptionRVX-208 98%
  • Packaging50mg
  • Price$780
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16424
  • Product descriptionRVX-208 ≥98%
  • Packaging25mg
  • Price$404
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16424
  • Product descriptionRVX-208 ≥98%
  • Packaging10mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16424
  • Product descriptionRVX-208 ≥98%
  • Packaging5mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16424
  • Product descriptionRVX-208 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM116104
  • Product description2-[4-(2-Hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one 95%
  • Packaging1g
  • Price$402
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3239
  • Product descriptionApabetalone 99.86%
  • Packaging5mg
  • Price$82
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Z3839 RVX-208 50mg $522.5 2021-12-16 Buy
American Custom Chemicals Corporation CHM0387744 2-(4-(2-HYDROXYETHOXY)-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE 95.00% 5MG $497.28 2021-12-16 Buy
ApexBio Technology B1499 RVX-208 5mg $68 2021-12-16 Buy
Biorbyt Ltd orb545916 RVX-208 >98% 25mg $508.3 2021-12-16 Buy
Biorbyt Ltd orb545916 RVX-208 >98% 5mg $187 2021-12-16 Buy
Biosynth Carbosynth FR137715 RVX 208 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FR137715 RVX 208 50mg $437.5 2021-12-16 Buy
BroadPharm BP-23380 RVX-208 98% 10mg $280 2021-12-16 Buy
BroadPharm BP-23380 RVX-208 98% 25mg $490 2021-12-16 Buy
BroadPharm BP-23380 RVX-208 98% 50mg $780 2021-12-16 Buy
Cayman Chemical 16424 RVX-208 ≥98% 25mg $404 2024-03-01 Buy
Cayman Chemical 16424 RVX-208 ≥98% 10mg $193 2024-03-01 Buy
Cayman Chemical 16424 RVX-208 ≥98% 5mg $109 2024-03-01 Buy
Cayman Chemical 16424 RVX-208 ≥98% 1mg $44 2024-03-01 Buy
Chemenu CM116104 2-[4-(2-Hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one 95% 1g $402 2021-12-16 Buy
ChemScene CS-3239 Apabetalone 99.86% 5mg $82 2021-12-16 Buy

Properties

Boiling point :594.2±60.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :-20°C (des.)
solubility :Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
form :solid
pka :14.21±0.10(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H371 May cause damage to organs Specific target organ toxicity, single exposure Category 2 Warning P260, P264, P270, P309+P311, P405,P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P309+P311 IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a selective antagonist of BET bromodomains, binding with 10-100-fold higher affinity for BD2 (IC50 = 0.04-0.28 μM) over BD1 (IC50 = 1.8-3.1 μM). RVX-208 causes the selective release of BET proteins from chromatin in cells. It interferes with the BET protein BRD4, resulting in an increased expression of apolipoprotein (Apo) A1 in cells, mice, monkeys, and humans. RVX-208 also reduces atherosclerosis in hyperlipidemic ApoE-deficient mice.

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