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ChemicalBook >> CAS DataBase List >> CO-1686

CO-1686

CO-1686 price.
  • $50 - $3510
  • Product name: CO-1686
  • CAS: 1374640-70-6
  • MF: C27H28F3N7O3
  • MW: 555.55
  • EINECS:-0
  • MDL Number:MFCD26793864
  • Synonyms:CO-1686;AVL-301;CNX-419;CO-1686 (AVL-301);CO-1686/CO1686;N-[3-[[2-[[4-(4-Acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide;Clovis CO-1686;CO-1686(free base)
29 prices
Selected condition：
Brand
  • A1 Biochem Labs
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 20mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 5g
  • 10mM(in 1mL DMSO)
  • 1g
  • ManufacturerA1 Biochem Labs
  • Product numberA1-04311
  • Product descriptionRociletinib
  • Packaging1g
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2334AH
  • Product descriptionCO-1686
  • Packaging100mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5708
  • Product descriptionCO-1686
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2334AH
  • Product descriptionCO-1686
  • Packaging10mg
  • Price$151
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3320
  • Product descriptionCO-1686(AVL-301)
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3320
  • Product descriptionCO-1686(AVL-301)
  • Packaging10mM(in 1mL DMSO)
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3320
  • Product descriptionCO-1686(AVL-301)
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3320
  • Product descriptionCO-1686(AVL-301)
  • Packaging50mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3320
  • Product descriptionCO-1686(AVL-301)
  • Packaging100mg
  • Price$255
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60291
  • Product descriptionRociletinib(CO-1686) ≥98%
  • Packaging20mg
  • Price$308
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180961
  • Product descriptionRociletinib (CO-1686) >99%
  • Packaging100mg
  • Price$414.8
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180961
  • Product descriptionRociletinib (CO-1686) >99%
  • Packaging250mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180961
  • Product descriptionRociletinib (CO-1686) >99%
  • Packaging1g
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA103658
  • Product descriptionRociletinib
  • Packaging250mg
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA103658
  • Product descriptionRociletinib
  • Packaging500mg
  • Price$1250
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA103658
  • Product descriptionRociletinib
  • Packaging1g
  • Price$1500
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
A1 Biochem Labs A1-04311 Rociletinib 1g $700 2021-12-16 Buy
AK Scientific 2334AH CO-1686 100mg $320 2021-12-16 Buy
AK Scientific SYN5708 CO-1686 10mg $160 2021-12-16 Buy
AK Scientific 2334AH CO-1686 10mg $151 2021-12-16 Buy
ApexBio Technology A3320 CO-1686(AVL-301) 5mg $50 2021-12-16 Buy
ApexBio Technology A3320 CO-1686(AVL-301) 10mM(in 1mL DMSO) $60 2021-12-16 Buy
ApexBio Technology A3320 CO-1686(AVL-301) 10mg $80 2021-12-16 Buy
ApexBio Technology A3320 CO-1686(AVL-301) 50mg $165 2021-12-16 Buy
ApexBio Technology A3320 CO-1686(AVL-301) 100mg $255 2021-12-16 Buy
Arctom CFN60291 Rociletinib(CO-1686) ≥98% 20mg $308 2021-12-16 Buy
Biorbyt Ltd orb180961 Rociletinib (CO-1686) >99% 100mg $414.8 2021-12-16 Buy
Biorbyt Ltd orb180961 Rociletinib (CO-1686) >99% 250mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb180961 Rociletinib (CO-1686) >99% 1g $1208.7 2021-12-16 Buy
Biosynth Carbosynth FA103658 Rociletinib 250mg $700 2021-12-16 Buy
Biosynth Carbosynth FA103658 Rociletinib 500mg $1250 2021-12-16 Buy
Biosynth Carbosynth FA103658 Rociletinib 1g $1500 2021-12-16 Buy

Properties

Melting point :202 - 205°C (dec.)
Density :1.372±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :13.23±0.70(Predicted)
color :Off-White
CAS DataBase Reference :1374640-70-6

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

CO-1686 is an irreversible kinase inhibitor that specifically targets mutant forms of the epidermal growth factor receptor (EGFR) including T790M (Ki = 21.5 nM) with significantly reduced activity at the wild-type form of the receptor (Ki = 303.3 nM). CO-1686 has been shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR with GI50 values ranging from 7-32 nM in vitro, inducing apoptosis. It also demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and transgenic models dosed orally at 100 mg/kg/day.

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