EGF816
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- $37 - $1571
- Product name: EGF816
- CAS: 1508250-71-2
- MF: C26H31ClN6O2
- MW: 495.02
- EINECS:
- MDL Number:MFCD28963918
- Synonyms:Nazartinib (EGF816);EGF816;Nazartinib;NVS-816;EGF816, 98%, a novel EGFR inhibitor;Nazartinib (EGF816, NVS-816);(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;EGF816 Nazartinib
18 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number3883DW
- Product descriptionNazartinib
- Packaging25mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005714
- Product description(R,E)-N-(7-CHLORO-1-(1-(4-(DIMETHYLAMINO)BUT-2-ENOYL)AZEPAN-3-YL)-1H-BENZO[D]IMIDAZOL-2-YL)-2-METHYLISONICOTINAMIDE 95.00%
- Packaging5MG
- Price$505.45
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5889
- Product descriptionEGF816
- Packaging10mg
- Price$299
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22409
- Product descriptionNazartinib ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22409
- Product descriptionNazartinib ≥98%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22409
- Product descriptionNazartinib ≥98%
- Packaging10mg
- Price$283
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22409
- Product descriptionNazartinib ≥98%
- Packaging25mg
- Price$599
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-4325
- Product descriptionNazartinib 99.57%
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4325
- Product descriptionNazartinib 99.57%
- Packaging10mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4325
- Product descriptionNazartinib 99.57%
- Packaging25mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4325
- Product descriptionNazartinib 99.57%
- Packaging50mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4325
- Product descriptionNazartinib 99.57%
- Packaging100mg
- Price$1250
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003329
- Product descriptionEGF816 98+%
- Packaging5mg
- Price$366
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003329
- Product descriptionEGF816 98+%
- Packaging10mg
- Price$524
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003329
- Product descriptionEGF816 98+%
- Packaging25mg
- Price$924
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003329
- Product descriptionEGF816 98+%
- Packaging50mg
- Price$1571
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3883DW | Nazartinib | 25mg | $765 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005714 | (R,E)-N-(7-CHLORO-1-(1-(4-(DIMETHYLAMINO)BUT-2-ENOYL)AZEPAN-3-YL)-1H-BENZO[D]IMIDAZOL-2-YL)-2-METHYLISONICOTINAMIDE 95.00% | 5MG | $505.45 | 2021-12-16 | Buy |
| ApexBio Technology | B5889 | EGF816 | 10mg | $299 | 2021-12-16 | Buy |
| Cayman Chemical | 22409 | Nazartinib ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 22409 | Nazartinib ≥98% | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 22409 | Nazartinib ≥98% | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 22409 | Nazartinib ≥98% | 25mg | $599 | 2024-03-01 | Buy |
| ChemScene | CS-4325 | Nazartinib 99.57% | 5mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-4325 | Nazartinib 99.57% | 10mg | $190 | 2021-12-16 | Buy |
| ChemScene | CS-4325 | Nazartinib 99.57% | 25mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-4325 | Nazartinib 99.57% | 50mg | $650 | 2021-12-16 | Buy |
| ChemScene | CS-4325 | Nazartinib 99.57% | 100mg | $1250 | 2021-12-16 | Buy |
| Crysdot | CD31003329 | EGF816 98+% | 5mg | $366 | 2021-12-16 | Buy |
| Crysdot | CD31003329 | EGF816 98+% | 10mg | $524 | 2021-12-16 | Buy |
| Crysdot | CD31003329 | EGF816 98+% | 25mg | $924 | 2021-12-16 | Buy |
| Crysdot | CD31003329 | EGF816 98+% | 50mg | $1571 | 2021-12-16 | Buy |
Properties
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Powder
pka :11.38±0.43(Predicted)
color :Off-white to yellow
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Powder
pka :11.38±0.43(Predicted)
color :Off-white to yellow
Safety Information
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Description
Nazartinib is an irreversible inhibitor of mutant EGF receptors (EGFRs). It is selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 non-small cell lung cancer cells (NSCLC; IC50 = 4.18 nM), over cells expressing wild-type EGFRs (IC50 = 160.6 nM for HaCaT keratinocytes). Nazartinib decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM, respectively) and inhibits cell proliferation (EC50s = 9, 11, and 25 nM, respectively) but does not affect cell proliferation in cell lines containing wild-type EGFR. It reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model when administered at doses ranging from 3 to 100 mg/kg per day for 21 days.More related product prices
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Suppliers and manufacturers
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