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ChemicalBook >> CAS DataBase List >> Amlodipine

Amlodipine

Amlodipine price.
  • $5 - $1732.5
  • Product name: Amlodipine
  • CAS: 88150-42-9
  • MF: C20H25ClN2O5
  • MW: 408.88
  • EINECS:1308068-626-2
  • MDL Number:MFCD00864687
  • Synonyms:AMLODIPINE MM(CRM STANDARD);Amlodipine∬AmlodipineBesylate/Maleate;3,5-Pyridinedicarboxylic acid, 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester;ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;Pelmec;Racemic Amlodipine;3,5-pyridinedicarboxylic acid, 1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor 3-ethyl 5-methyl ester
37 prices
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Brand
  • Abosyn
  • Alfa Aesar
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • TRC
Package
  • 10mM(in 1mL DMSO)
  • 1MG
  • 1unit
  • 10MG
  • 25mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • 2g
  • 5g
  • 10g
  • 25g
  • 100g
  • ManufacturerAbosyn
  • Product number61-11487
  • Product descriptionAmlodipine 95-98%
  • Packaging1g
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAbosyn
  • Product number61-11487
  • Product descriptionAmlodipine 95-98%
  • Packaging5g
  • Price$405
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62242
  • Product descriptionAmlodipine, 97+%
  • Packaging1g
  • Price$110.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62242
  • Product descriptionAmlodipine, 97+%
  • Packaging5g
  • Price$420.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ62242
  • Product descriptionAmlodipine, 97+%
  • Packaging10g
  • Price$601.65
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA367713
  • Product description3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+%
  • Packaging25mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA367713
  • Product description3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+%
  • Packaging100mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA367713
  • Product description3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+%
  • Packaging5g
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA367713
  • Product description3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+%
  • Packaging10g
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA367713
  • Product description3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+%
  • Packaging25g
  • Price$41
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA367713
  • Product description3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+%
  • Packaging100g
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006658
  • Product descriptionAMLODIPINE-D4-MALEATE 95.00%
  • Packaging1MG
  • Price$721.88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005963
  • Product descriptionAMLODIPINE 95.00%
  • Packaging10MG
  • Price$739.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006658
  • Product descriptionAMLODIPINE-D4-MALEATE 95.00%
  • Packaging10MG
  • Price$1732.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1410
  • Product descriptionAmlodipine
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1410
  • Product descriptionAmlodipine
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Abosyn 61-11487 Amlodipine 95-98% 1g $65 2021-12-16 Buy
Abosyn 61-11487 Amlodipine 95-98% 5g $405 2021-12-16 Buy
Alfa Aesar J62242 Amlodipine, 97+% 1g $110.65 2024-03-01 Buy
Alfa Aesar J62242 Amlodipine, 97+% 5g $420.65 2024-03-01 Buy
Alfa Aesar J62242 Amlodipine, 97+% 10g $601.65 2024-03-01 Buy
Ambeed A367713 3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+% 25mg $5 2021-12-16 Buy
Ambeed A367713 3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+% 100mg $7 2021-12-16 Buy
Ambeed A367713 3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+% 5g $11 2021-12-16 Buy
Ambeed A367713 3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+% 10g $20 2021-12-16 Buy
Ambeed A367713 3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+% 25g $41 2021-12-16 Buy
Ambeed A367713 3-Ethyl5-methyl2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 99+% 100g $147 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006658 AMLODIPINE-D4-MALEATE 95.00% 1MG $721.88 2021-12-16 Buy
American Custom Chemicals Corporation API0005963 AMLODIPINE 95.00% 10MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006658 AMLODIPINE-D4-MALEATE 95.00% 10MG $1732.5 2021-12-16 Buy
ApexBio Technology B1410 Amlodipine 1unit $28 2021-12-16 Buy
ApexBio Technology B1410 Amlodipine 10mM(in 1mL DMSO) $50 2021-12-16 Buy

Properties

Melting point :178-179°C
Boiling point :527.2±50.0 °C(Predicted)
Density :1.227±0.06 g/cm3(Predicted)
RTECS :US7968329
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka :pKa 8.6 (Uncertain)
form :Almost white crystal powder
color :White
Water Solubility :75.3 mg/L
BCS Class :1
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference :88150-42-9(CAS DataBase Reference)
EPA Substance Registry System :3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle. Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. When used in combination with the angiotensin receptor blocker olmesartan, amlopidine has been shown to potentiate antihypertensive activity. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition.

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