| Identification | More | [Name]
Amlodipine | [CAS]
88150-42-9 | [Synonyms]
AMLODIPINE
AMLODIPINE BASE
LOTREL
methyl ethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3,5-pyridinedicarboxylicacid,1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor
3-ethyl5-methylester
Amlodipin
besylate
AMLODIPINE MM(CRM STANDARD)
Amlodipine&Int
AmlodipineBesylate/Maleate
3,5-Pyridinedicarboxylic acid, 2-(2-aminoethoxy)methyl-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
ethyl methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Pelmec
Racemic Amlodipine
3,5-pyridinedicarboxylic acid, 1,4-dihydro-2-((2-aminoethoxy)methyl)-4-(2-chlor 3-ethyl 5-methyl ester
Amlodipine (base and/or unspecified salts)
Methyl ethyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
AMLODIPINE (BASE & SALTS)
Amlodipine ( Amlodipine Benzenesulfonate) | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C26H31ClN2O8S | [MDL Number]
MFCD00864687 | [Molecular Weight]
567.05 | [MOL File]
88150-42-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
178-179°C | [Boiling point ]
527.2±50.0 °C(Predicted) | [density ]
1.227±0.06 g/cm3(Predicted) | [RTECS ]
US7968329 | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). | [form ]
Almost white crystal powder | [pka]
pKa 8.6 (Uncertain) | [color ]
White | [Water Solubility ]
75.3 mg/L | [Usage]
A dihydropyridine. | [BCS Class]
1 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months. | [CAS DataBase Reference]
88150-42-9(CAS DataBase Reference) | [EPA Substance Registry System]
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9) |
| Hazard Information | Back Directory | [Hazard]
Human systemic effects.
| [Description]
Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.1 Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.2 Formulations containing amlodipine have been used in the treatment of hypertension. | [Chemical Properties]
Yellow Solid | [Uses]
A deuterated dihydropyridine calcium channel blocker.;Application of Labeled APIs: Labeled Amlodipine, intended for use as an internal standard for the quantification of Amlodipine by GC- or LC-mass spectrometry. | [Uses]
A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer. | [Uses]
anti-hypertensive;calcium channel blocker | [Definition]
ChEBI: A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina. | [Brand name]
Norvasc (Pfizer). | [General Description]
Amlodipine, 2-[, for the treatment of hypertension. Amlodipineis also marketed as a combination therapy with atorvastatinunder the tradename Norvasc for the management of highcholesterol and high blood pressure. | [Clinical Use]
Calcium-channel blocker:
Hypertension
Angina prophylaxis | [Safety Profile]
Human systemic effects. Whenheated to decomposition it emits toxic vapors of NOx andCl-. | [Drug interactions]
Potentially hazardous interactions with other drugs
Aminophylline and theophylline: possibly increased
aminophylline and theophylline concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials: metabolism possibly inhibited by
clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with
MAOIs, concentration possibly reduced by St John’s
wort.
Antiepileptics: effects probably reduced by
phenobarbital and primidone.
Antifungals: negative inotropic effect possibly
increased with itraconazole.
Antihypertensives: enhanced hypotensive effect;
increased risk of first dose hypotensive effect of postsynaptic alpha-blockers.
Antivirals: concentration increased by telaprevir and
possibly by ritonavir - reduce dose of amlodipine.
Ciclosporin: ciclosporin concentration may be
increased by up to 40%.
Lipid lowering agents: possibly increased risk of
myopathy - do not exceed 20 mg of simvastatin.1 Tacrolimus: possibly increased tacrolimus levels. | [Metabolism]
Amlodipine is extensively metabolised by the liver to
inactive metabolites with 10% of the parent compound
and 60% of metabolites excreted in the urine. | [References]
1) Mason et al. (2003), Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine; Arterioscler. Thromb. Vasc. Biol., 23 2155
2) Asano et al. (2003), A calcium channel blocker activates both ecto-5(‘)-nucleotidase and NO synthase in HUVEC; Biochem. Biophys. Res. Commun., 311 625
3) Yu et al. (2003), Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction; Hypertension, 42 329
4) Zhou et al. (2004), Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats; Am. J. Hypertension, 17 167
5) Ueda et al. (1993), A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects; Br. J. Clin. Pharmacol., 36 561 |
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