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ChemicalBook >> CAS DataBase List >> Alvespimycin

Alvespimycin

Alvespimycin price.
  • $30 - $912.9
  • Product name: Alvespimycin
  • CAS: 467214-20-6
  • MF: C32H48N4O8
  • MW: 616.75
  • EINECS:
  • MDL Number:MFCD08457919
  • Synonyms:17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG;17-DMAGhydrochloride;Alvespimycin;17-DMAG (Alvespimycin);Unii-001L2fe0m3;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride;17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin;17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin-d6
19 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • American Custom Chemicals Corporation
  • Biorbyt Ltd
  • Cayman Chemical
  • Crysdot
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 1
  • 100ug
  • 2.5mg
  • 5MG
  • 10mg
  • 25mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0540-M001
  • Product description17-DMAG ≥98%(HPLC)
  • Packaging1mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028031
  • Product description17-DIMETHYLAMINOGELDANAMYCIN 95.00%
  • Packaging5MG
  • Price$456.98
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545846
  • Product description17-DMAG >98%
  • Packaging1mg
  • Price$154.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545846
  • Product description17-DMAG >98%
  • Packaging5mg
  • Price$289
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611526
  • Product descriptionAlvespimycin
  • Packaging1g
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611526
  • Product descriptionAlvespimycin
  • Packaging250mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611526
  • Product descriptionAlvespimycin
  • Packaging100mg
  • Price$397.8
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11036
  • Product description17-DMAG ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11036
  • Product description17-DMAG ≥98%
  • Packaging5mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11036
  • Product description17-DMAG ≥98%
  • Packaging10mg
  • Price$195
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001849
  • Product description17-DMAG 98+%
  • Packaging10mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001849
  • Product description17-DMAG 98+%
  • Packaging25mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001849
  • Product description17-DMAG 98+%
  • Packaging100mg
  • Price$191
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number2610
  • Product description17-DMAGhydrochloride ≥99%(HPLC)
  • Packaging1
  • Price$255
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD678403
  • Product description17-DMAG
  • Packaging2.5mg
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD470932
  • Product description17-N-(2-Dimethylaminoethylamino)-17-demethoxyGeldanamycin-d6
  • Packaging1mg
  • Price$155
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0540-M001 17-DMAG ≥98%(HPLC) 1mg $30 2021-12-16 Buy
American Custom Chemicals Corporation API0028031 17-DIMETHYLAMINOGELDANAMYCIN 95.00% 5MG $456.98 2021-12-16 Buy
Biorbyt Ltd orb545846 17-DMAG >98% 1mg $154.7 2021-12-16 Buy
Biorbyt Ltd orb545846 17-DMAG >98% 5mg $289 2021-12-16 Buy
Biorbyt Ltd orb611526 Alvespimycin 1g $912.9 2021-12-16 Buy
Biorbyt Ltd orb611526 Alvespimycin 250mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb611526 Alvespimycin 100mg $397.8 2021-12-16 Buy
Cayman Chemical 11036 17-DMAG ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 11036 17-DMAG ≥98% 5mg $116 2024-03-01 Buy
Cayman Chemical 11036 17-DMAG ≥98% 10mg $195 2024-03-01 Buy
Crysdot CD31001849 17-DMAG 98+% 10mg $49 2021-12-16 Buy
Crysdot CD31001849 17-DMAG 98+% 25mg $70 2021-12-16 Buy
Crysdot CD31001849 17-DMAG 98+% 100mg $191 2021-12-16 Buy
Tocris 2610 17-DMAGhydrochloride ≥99%(HPLC) 1 $255 2021-12-16 Buy
TRC D678403 17-DMAG 2.5mg $315 2021-12-16 Buy
TRC D470932 17-N-(2-Dimethylaminoethylamino)-17-demethoxyGeldanamycin-d6 1mg $155 2021-12-16 Buy

Properties

Melting point :>270°C (dec.)
Boiling point :810.5±65.0 °C(Predicted)
Density :1.20
storage temp. :Desiccate at -20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :8.48±0.70(Predicted)
color :Very Dark Purple

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.

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