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ChemicalBook--->CAS DataBase List--->467214-20-6

467214-20-6

467214-20-6 Structure

467214-20-6 Structure
IdentificationBack Directory
[Name]

Alvespimycin
[CAS]

467214-20-6
[Synonyms]

17-DMAG
CS-2382
DMAG-d6
17-DMAG-d6
Alvespimycin
NSC 707545-d6
AlvespiMycin-d6
Unii-001L2fe0m3
In-house Standard
DMAG Hydrochloride
17-DMAGhydrochloride
AlvespiMycin freebase
AlvespiMycin(17-DMAG)
17-DMAG (Alvespimycin)
NSC 707545 Hydrochloride
(150270-08-9) alvespimycin
17-DMAG;KOS-1022;NSC-707545
17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG
17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin
17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin
17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
17-N-[(diMethyl-d6)aMinoethylaMino]-17-deMethoxygeldanaMycin
17DMAG (17-diMethylaMinoethylaMino-17-deMethoxy-geldanaMycin)
17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin-d6
17-[2-[(DiMethyl-d6)aMino]ethylaMino]-17-desMethylgeldanaMycin
Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-
17-DeMethoxy-17-[[2-[(diMethyl-d6)aMino]ethyl]aMino]geldanaMycin
17-[2-(DiMethylaMino)ethylaMino]-17-desMethylgeldanaMycin Hydrochloride
17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxygeldanaMycin Hydrochloride
17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride
17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin Hydrochloride
17-DMAG/ Alvespimycin/ 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
[Molecular Formula]

C32H48N4O8
[MDL Number]

MFCD08457919
[MOL File]

467214-20-6.mol
[Molecular Weight]

616.75
Chemical PropertiesBack Directory
[Melting point ]

>270°C (dec.)
[density ]

1.20
[storage temp. ]

Desiccate at -20°C
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

Very Dark Purple
Safety DataBack Directory
[HS Code ]

29419090
Hazard InformationBack Directory
[Description]

Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.
[Chemical Properties]

Solid
[Uses]

17-DMAG is a synthetic Geldanamycin derivative and inhibitor of Hsp90.
[Uses]

17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
[Uses]

The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
[Definition]

ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.
[Biological Activity]

Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
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