Product Details
| Product Name:
Alvespimycin |
CAS No.:
467214-20-6 |
| Min. Order:
1G |
Purity:
98% |
| Supply Ability:
100KG |
Release date:
2019/07/06 |
AD68
| Alvespimycin Basic information |
| Product Name: |
Alvespimycin |
| Synonyms: |
17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG;17-DMAGhydrochloride;17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin;Alvespimycin;17-DMAG (Alvespimycin);17-DMAG;Unii-001L2fe0m3 |
| CAS: |
467214-20-6 |
| MF: |
C32H48N4O8 |
| MW: |
616.74552 |
| EINECS: |
|
| Product Categories: |
Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds |
| Mol File: |
467214-20-6.mol |
 |
| |
| Alvespimycin Chemical Properties |
| density |
1.20 |
| storage temp. |
Desiccate at -20°C |
| |
| Alvespimycin Usage And Synthesis |
| Chemical Properties |
Solid |
| Uses |
17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG. |
| Uses |
The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG. |
| Definition |
ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group. |
| Biological Activity |
Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively). |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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