5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile
![5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile price.](/CAS2/GIF/905586-69-8.gif)
|
- $60 - $5760
- Product name: 5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile
- CAS: 905586-69-8
- MF: C18H16F2N6
- MW: 354.36
- EINECS:
- MDL Number:MFCD16621127
- Synonyms:5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile;AZ 960;(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylaMino)-6-(5-Methyl-1H-pyrazol-3-ylaMino)nicotinonitrile;5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile AZ 960;(S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonit;CS-184;3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-;5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile ISO 9001：2015 REACH
24 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
Package
- 1mg
- 2x2mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100mg
- 250mg
- 5g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3752-M001
- Product descriptionAZ960 ≥95%
- Packaging1mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1015-M005
- Product descriptionAZ-960 ≥95%
- Packaging5mg
- Price$367
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1015
- Product descriptionAZ-960
- Packaging1mg
- Price$155
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000380
- Product descriptionAZ-960 95.00%
- Packaging1MG
- Price$271.95
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000380
- Product descriptionAZ-960 95.00%
- Packaging5MG
- Price$968
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000380
- Product descriptionAZ-960 95.00%
- Packaging25MG
- Price$1963.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4144
- Product descriptionAZ960
- Packaging5mg
- Price$315
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4144
- Product descriptionAZ960
- Packaging10mg
- Price$473
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1778
- Product descriptionAZ960 98%
- Packaging2x2mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16731
- Product descriptionAZ 960 ≥98%
- Packaging1mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16731
- Product descriptionAZ 960 ≥98%
- Packaging5mg
- Price$404
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16731
- Product descriptionAZ 960 ≥98%
- Packaging10mg
- Price$636
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM244368
- Product description(S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile 97%
- Packaging10mg
- Price$194
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM244368
- Product description(S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile 97%
- Packaging50mg
- Price$511
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6209
- Product descriptionAZ960 >98.0%
- Packaging1mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6209
- Product descriptionAZ960 >98.0%
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3752-M001 | AZ960 ≥95% | 1mg | $60 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1015-M005 | AZ-960 ≥95% | 5mg | $367 | 2021-12-16 | Buy |
| AK Scientific | SYN1015 | AZ-960 | 1mg | $155 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000380 | AZ-960 95.00% | 1MG | $271.95 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000380 | AZ-960 95.00% | 5MG | $968 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000380 | AZ-960 95.00% | 25MG | $1963.5 | 2021-12-16 | Buy |
| ApexBio Technology | A4144 | AZ960 | 5mg | $315 | 2021-12-16 | Buy |
| ApexBio Technology | A4144 | AZ960 | 10mg | $473 | 2021-12-16 | Buy |
| Axon Medchem | Axon1778 | AZ960 98% | 2x2mg | $154 | 2021-12-16 | Buy |
| Cayman Chemical | 16731 | AZ 960 ≥98% | 1mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 16731 | AZ 960 ≥98% | 5mg | $404 | 2024-03-01 | Buy |
| Cayman Chemical | 16731 | AZ 960 ≥98% | 10mg | $636 | 2024-03-01 | Buy |
| Chemenu | CM244368 | (S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile 97% | 10mg | $194 | 2021-12-16 | Buy |
| Chemenu | CM244368 | (S)-5-Fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile 97% | 50mg | $511 | 2021-12-16 | Buy |
| ChemScene | CS-6209 | AZ960 >98.0% | 1mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-6209 | AZ960 >98.0% | 5mg | $150 | 2021-12-16 | Buy |
Properties
Boiling point :515.2±50.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :crystalline solid
pka :13.42±0.10(Predicted)
color :Light yellow to yellow
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :crystalline solid
pka :13.42±0.10(Predicted)
color :Light yellow to yellow
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma. AZ 960 inhibits JAK2 with a Ki value of 0.45 nM in vitro. It can decrease STAT3/5 phosphorylation and inhibit cell proliferation in a SET-2 human megakaryoblastic cell line that is heterozygous for the JAK2 V617F mutation with a GI50 value of 33 nM. AZ 960 can also induce apoptosis in human T cell lymophotropic virus type 1-infected (IC50 = ~1 μM), which corresponds to a downregulation of phosphorylated forms of JAK2 and Bcl-2 family proteins.Related product price
- Olaparib
$28-2147.1 - 1062368-24-4
$35-3306 - BI 2536
$37-2839
Suppliers and manufacturers
career henan chemical co
![5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile](https://img.chemicalbook.com/ProductImageEN/2018-12/small/0d29a12c-2ca6-431a-b0b8-b91eca49647d.png)
Hubei xin bonus chemical co. LTD
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nanjing Doge Biomedical Technology Co., Ltd
TargetMol Chemicals Inc.
$2.00 /1kg
5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile CAS:905586-69-8
5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile CAS:905586-69-8
![5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile](/ProductImageEN/2021-04/small/c40cf679-9dc2-491f-8b3e-146a856ec8b9.png){kind=small}