AZ 960

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1778

CAS [905586-69-8]

MF C18H16F2N6
MW 354.36

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

AZ 960

Description

Potent, selective and ATP-competitive JAK2 inhibitor; AZ960 inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell

JM Gozgit et al. Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2. J. Biol. Chem. 2008, 283(47), 32334-32343.

J Yang et al. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010, 9(12), 3386-3395.

Apoptosis Cell Signaling & Oncology Epigenetics JAK-STAT EC 2.7.10.2 JAK

JAK2 inhibitor

Chemical name

(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile

Parent CAS No.

[905586-69-8]

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Size	Unit Price	Stock
2 mg	$104.50	In Stock
5 mg	$148.50	In Stock

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Size	Unit Price	Stock
2 x 2 mg	$154.00	In Stock
2 x 5 mg	$220.00	In Stock

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AZ 960

Description

Chemical name

Parent CAS No.

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