5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
![5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime price.](/CAS2/GIF/405554-55-4.gif)
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- $49 - $11166
- Product name: 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
- CAS: 405554-55-4
- MF: C27H27N5O2
- MW: 453.54
- EINECS:
- MDL Number:MFCD16038645
- Synonyms:5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime;1H-Inden-1-one, 5-[2-[4-[2-(diMethylaMino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-iMidazol-4-yl]-2,3-dihydro-, oxiMe;GSK 2118436(SB 590885);SB590885(GSK2118436);5-[2-[4-[2-(DiMethylaMino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-iMidazol-4-yl]-2,3-dihydro-1H-inden-1-on;(E)-5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5-yl)-2,3-dihydroinden-1-one oxime;SB590885;GSK 2118436
45 prices
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Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5mg
- 10
- 1mg
- 10mg
- 25mg
- 2x25mg
- 50mg
- 50
- 10mM(in 1mL DMSO)
- 100mg
- 250mg
- 1000mg
- 1g
- 10g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1077-M100
- Product descriptionSB590885 ≥95%
- Packaging100mg
- Price$1177
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0277
- Product descriptionSB-590885
- Packaging250mg
- Price$3047
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA720977
- Product description5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+%
- Packaging5mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA720977
- Product description5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+%
- Packaging10mg
- Price$176
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA720977
- Product description5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+%
- Packaging50mg
- Price$448
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA720977
- Product description5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+%
- Packaging100mg
- Price$672
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000231
- Product descriptionSB-590885 95.00%
- Packaging10MG
- Price$739.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000231
- Product descriptionSB-590885 95.00%
- Packaging50MG
- Price$1328.25
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1406
- Product descriptionSB590885
- Packaging10mM(in 1mL DMSO)
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1406
- Product descriptionSB590885
- Packaging50mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0159
- Product descriptionSB-590885
- Packaging1mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0159
- Product descriptionSB-590885
- Packaging5mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0159
- Product descriptionSB-590885
- Packaging10mg
- Price$203
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60336
- Product descriptionSB590885 ≥98%
- Packaging5mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2504
- Product descriptionSB590885 99%
- Packaging5mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2504
- Product descriptionSB590885 99%
- Packaging2x25mg
- Price$572
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1077-M100 | SB590885 ≥95% | 100mg | $1177 | 2021-12-16 | Buy |
| AK Scientific | Y0277 | SB-590885 | 250mg | $3047 | 2021-12-16 | Buy |
| Ambeed | A720977 | 5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+% | 5mg | $104 | 2021-12-16 | Buy |
| Ambeed | A720977 | 5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+% | 10mg | $176 | 2021-12-16 | Buy |
| Ambeed | A720977 | 5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+% | 50mg | $448 | 2021-12-16 | Buy |
| Ambeed | A720977 | 5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+% | 100mg | $672 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000231 | SB-590885 95.00% | 10MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000231 | SB-590885 95.00% | 50MG | $1328.25 | 2021-12-16 | Buy |
| ApexBio Technology | B1406 | SB590885 | 10mM(in 1mL DMSO) | $150 | 2021-12-16 | Buy |
| ApexBio Technology | B1406 | SB590885 | 50mg | $480 | 2021-12-16 | Buy |
| Apolloscientific | BISN0159 | SB-590885 | 1mg | $66 | 2021-12-16 | Buy |
| Apolloscientific | BISN0159 | SB-590885 | 5mg | $124 | 2021-12-16 | Buy |
| Apolloscientific | BISN0159 | SB-590885 | 10mg | $203 | 2021-12-16 | Buy |
| Arctom | CFN60336 | SB590885 ≥98% | 5mg | $208 | 2021-12-16 | Buy |
| Axon Medchem | Axon2504 | SB590885 99% | 5mg | $104.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2504 | SB590885 99% | 2x25mg | $572 | 2021-12-16 | Buy |
Properties
Density :1.27
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
color :white to beige
InChIKey :MLSAQOINCGAULQ-QLTSDVKISA-N
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
color :white to beige
InChIKey :MLSAQOINCGAULQ-QLTSDVKISA-N
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. SB-590885 is a potent inhibitor of B-Raf (Kd = 0.3 nM). It less effectively inhibits c-Raf (Ki = 1.72 nM) and has little effect at 46 other kinases. SB-590885 blocks activation of ERK1/2 and anchorage-independent cell proliferation of melanoma cells with either wild type or V600E B-Raf at nanomolar concentrations. Melanoma cells expressing the B-RafV600E mutation can drive invasion through alternative pathways in the presence of SB-590885, suggesting that combination therapy is needed to completely block cell invasion. SB-590885 has also been used to study the role of B-Raf in cerebral ischemia.Related product price
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Suppliers and manufacturers
career henan chemical co
![5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime](https://img.chemicalbook.com/ProductImageEN/2018-12/small/0d29a12c-2ca6-431a-b0b8-b91eca49647d.png)
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei xin bonus chemical co. LTD
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
$2.00 /1kg
5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime CAS:405554-55-4
5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime CAS:405554-55-4
