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ChemicalBook >> CAS DataBase List >> 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- price.
  • $12 - $1850
  • Product name: 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
  • CAS: 314771-88-5
  • MF: C18H14ClFN4O4
  • MW: 404.78
  • EINECS:925-395-5
  • MDL Number:MFCD18642924
  • Synonyms:7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl)aMino-6-nitroquinazoline;N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinaMine;Afatinib intermediate C;4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-;(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-aMine;N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl];N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-;N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine
24 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • Ambeed
  • Chemenu
  • ChemScene
  • Crysdot
  • TRC
Package
  • 100mg
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  • 1g
  • 5g
  • 10g
  • 25g
  • 100g
  • ManufacturerAK Scientific
  • Product number3302AH
  • Product description4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
  • Packaging5g
  • Price$384
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3302AH
  • Product description4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
  • Packaging25g
  • Price$1113
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number314771885
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
  • Packaging5g
  • Price$254.8
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number314771885
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
  • Packaging10g
  • Price$390
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number314771885
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
  • Packaging25g
  • Price$787.8
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA459816
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97%
  • Packaging100mg
  • Price$12
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA459816
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97%
  • Packaging250mg
  • Price$17
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA459816
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97%
  • Packaging1g
  • Price$42
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA459816
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97%
  • Packaging5g
  • Price$162
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA459816
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97%
  • Packaging25g
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA459816
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97%
  • Packaging100g
  • Price$1850
  • Updated2021-12-16
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  • ManufacturerChemenu
  • Product numberCM142470
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 95%
  • Packaging5g
  • Price$224
  • Updated2021-12-16
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  • ManufacturerChemenu
  • Product numberCM142470
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 95%
  • Packaging10g
  • Price$365
  • Updated2021-12-16
  • Buy
  • ManufacturerChemenu
  • Product numberCM142470
  • Product description(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 95%
  • Packaging25g
  • Price$729
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-M0992
  • Product description(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
  • Packaging1g
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-M0992
  • Product description(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
  • Packaging5g
  • Price$217
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3302AH 4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- 5g $384 2021-12-16 Buy
AK Scientific 3302AH 4-Quinazolinamine,N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- 25g $1113 2021-12-16 Buy
Alichem 314771885 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 5g $254.8 2021-12-16 Buy
Alichem 314771885 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 10g $390 2021-12-16 Buy
Alichem 314771885 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 25g $787.8 2021-12-16 Buy
Ambeed A459816 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97% 100mg $12 2021-12-16 Buy
Ambeed A459816 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97% 250mg $17 2021-12-16 Buy
Ambeed A459816 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97% 1g $42 2021-12-16 Buy
Ambeed A459816 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97% 5g $162 2021-12-16 Buy
Ambeed A459816 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97% 25g $550 2021-12-16 Buy
Ambeed A459816 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 97% 100g $1850 2021-12-16 Buy
Chemenu CM142470 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 95% 5g $224 2021-12-16 Buy
Chemenu CM142470 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 95% 10g $365 2021-12-16 Buy
Chemenu CM142470 (S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine 95% 25g $729 2021-12-16 Buy
ChemScene CS-M0992 (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine 1g $50 2021-12-16 Buy
ChemScene CS-M0992 (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine 5g $217 2021-12-16 Buy

Properties

Boiling point :585.0±50.0 °C(Predicted)
Density :1.534±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
pka :5.07±0.70(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib (A355305) which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

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