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ChemicalBook >> CAS DataBase List >> 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE

5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE price.
  • $44 - $5383
  • Product name: 5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE
  • CAS: 163769-88-8
  • MF: C22H21N3O2
  • MW: 359.42
  • EINECS:
  • MDL Number:MFCD00354370
  • Synonyms:Benz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-;5,6-DIHYDRO-2,3-DIMETHOXY-6,6-DIMETHYLBENZ[7,8]INDOLIZINO[2,3-B]QUINOXALINE;YM 90709;2,3-Dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline;YM 90709;YM90709;YM-90709;YM-90709,GM-CSF,inhibit,Inhibitor,Interleukin Related,IL-5,eosinophils,IL-5R,JAK2
29 prices
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Brand
  • aablocks
  • AK Scientific
  • Ambeed
  • Arctom
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Tocris
  • TRC
Package
  • 10
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • Manufactureraablocks
  • Product numberAA001UB5
  • Product descriptionBenz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl- 99%
  • Packaging5mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA001UB5
  • Product descriptionBenz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl- 99%
  • Packaging10mg
  • Price$219
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA001UB5
  • Product descriptionBenz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl- 99%
  • Packaging25mg
  • Price$369
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA001UB5
  • Product descriptionBenz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl- 99%
  • Packaging50mg
  • Price$635
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number4791CE
  • Product description16,17-Dimethoxy-21,21-dimethyl-1,3,10-triazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-2,4,6,8,10,12,14,16,18-nonaene
  • Packaging5mg
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number4791CE
  • Product description16,17-Dimethoxy-21,21-dimethyl-1,3,10-triazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-2,4,6,8,10,12,14,16,18-nonaene
  • Packaging10mg
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number4791CE
  • Product description16,17-Dimethoxy-21,21-dimethyl-1,3,10-triazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-2,4,6,8,10,12,14,16,18-nonaene
  • Packaging50mg
  • Price$154
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA265624
  • Product descriptionYM-90709 98+%
  • Packaging1g
  • Price$5383
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA265624
  • Product descriptionYM-90709 98+%
  • Packaging25mg
  • Price$447
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA265624
  • Product descriptionYM-90709 98+%
  • Packaging10mg
  • Price$263
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA265624
  • Product descriptionYM-90709 98+%
  • Packaging5mg
  • Price$155
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA265624
  • Product descriptionYM-90709 98+%
  • Packaging1mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS500451
  • Product descriptionYM-90709 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23448
  • Product descriptionYM-90709 ≥98%
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23448
  • Product descriptionYM-90709 ≥98%
  • Packaging10mg
  • Price$166
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23448
  • Product descriptionYM-90709 ≥98%
  • Packaging25mg
  • Price$365
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA001UB5 Benz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl- 99% 5mg $144 2021-12-16 Buy
aablocks AA001UB5 Benz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl- 99% 10mg $219 2021-12-16 Buy
aablocks AA001UB5 Benz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl- 99% 25mg $369 2021-12-16 Buy
aablocks AA001UB5 Benz[7,8]indolizino[2,3-b]quinoxaline,5,6-dihydro-2,3-dimethoxy-6,6-dimethyl- 99% 50mg $635 2021-12-16 Buy
AK Scientific 4791CE 16,17-Dimethoxy-21,21-dimethyl-1,3,10-triazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-2,4,6,8,10,12,14,16,18-nonaene 5mg $97 2021-12-16 Buy
AK Scientific 4791CE 16,17-Dimethoxy-21,21-dimethyl-1,3,10-triazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-2,4,6,8,10,12,14,16,18-nonaene 10mg $109 2021-12-16 Buy
AK Scientific 4791CE 16,17-Dimethoxy-21,21-dimethyl-1,3,10-triazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-2,4,6,8,10,12,14,16,18-nonaene 50mg $154 2021-12-16 Buy
Ambeed A265624 YM-90709 98+% 1g $5383 2021-12-16 Buy
Ambeed A265624 YM-90709 98+% 25mg $447 2021-12-16 Buy
Ambeed A265624 YM-90709 98+% 10mg $263 2021-12-16 Buy
Ambeed A265624 YM-90709 98+% 5mg $155 2021-12-16 Buy
Ambeed A265624 YM-90709 98+% 1mg $44 2021-12-16 Buy
Arctom AS500451 YM-90709 ≥98% 1mg $44 2021-12-16 Buy
Cayman Chemical 23448 YM-90709 ≥98% 5mg $93 2024-03-01 Buy
Cayman Chemical 23448 YM-90709 ≥98% 10mg $166 2024-03-01 Buy
Cayman Chemical 23448 YM-90709 ≥98% 25mg $365 2024-03-01 Buy

Properties

Boiling point :579.6±50.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml
form :A crystalline solid
pka :2.74±0.40(Predicted)
color :Brown to orange

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC50 values of 1 and 0.57 μM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay. It inhibits IL-5-induced eosinophil survival (IC50 = 0.45 μM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED50s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED50 = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.

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