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5119-48-2
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WITHAFERIN A
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NSC 273757;nsc-101088;upeferinA.;Withaferine;WITHAFERIN A;withaferinea;Withaferin A-RM;Withaferin A Standard;Withaferin A 5119-48-2;delta-lactone,(20s,22r)-oxo
CBNumber:
CB9454365
???:
C28H38O6
??? ??:
470.6
MOL ??:
5119-48-2.mol
MSDS ??:
SDS

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252-253℃
??
D28 +125° (c = 1.30 in CHCl3)
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680.7±55.0 °C(Predicted)
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1.28
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226℃
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Desiccate at -20°C
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DMSO? ???(?? 20mg/ml)
?? ?? (pKa)
13.49±0.70(Predicted)
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plant (Withania somnifera)
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??? ?? ?????? 1? ?? ??????. DMSO? ???? -20°C?? ?? 1?? ?? ??? ? ????.
InChIKey
DBRXOUCRJQVYJQ-CKNDUULBSA-N
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
WGK ?? 3
RTECS ?? KE7288500
HS ?? 29322090
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
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P261 ??·?·??·???·??·...·????? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.

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Solid

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ChEBI: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Phys lis longifolia, it exhibits cytotoxic activity.

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Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) spouting in vitro (IC 50 = 12 nM) and in vivo . Prevents NF- κ B activation by inhibiting activation of IKK β . Also inhibits chymotrypsin-like activity of the 20S proteasome.

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