????????#300 ??

????????#300 MSDS

PEG

????????#300 C??? ??, ??, ??

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????? ???? ? ???? ???. ??? ??, ??? ??? ?? ???? ??? ???? ???? PEG? ????? ???? ??. ????(hybridoma)? ??? ? ????. ??? ??? ???? PEG? ?? ???? ??? ?? ??? ????? ???? ??? ?? ???? ????? ?? ??. PEG? ???, ?? ?? ??? ?? ???2??? ???????? ????.

????

? (1) ? ?? ???(1→20)? pH? 4.5～7.5??.

?(2) ??(?????) : ? ?? 6g? ???????? 2??? ????? 50mL? ?? 0.1N ????????????? ?? ??? 15?? ??? ??? ??? ?, ? ???? 0.5mL ????? ??.

?(3) ?? : ? ??? ????? ?1? ??? ?????? ?? 100±0.3℃?? ??? ? ? ??? ???? ??? ??? ??.

???※ ? ?? ?? ???? ????? ?? ??? ???(內(nèi)揷法)?? ???.

?(4) 1,4-??? : ? ?? 0.5g? ?????(???? ??) 0.1g? ? 10mL? ??? 10?? ???? ???? ?? ?????? ?? 25mL ?????? ??(Frit sparger)? ?? ??? ??? 50℃? ????? ????? ? ?????????? ????. ??, ? 10mL? 1,4-??? 5μg? ????? ? ??? ????? 0.1g? ?? ?? ?????? ?? ?? ??? ???? ????(10ppm ??).

??????

???????

??????? ? : Vorcarb 3000 ?? ?? ??? ?

??????? : 11?

??????? ? ?? : 250℃, 4?

??????? ??(Cryo focus temp.) : -150℃

?????? ??(Bake temp.) ? ?? : 260℃, 10?

???????????

??????? ? : HP-FFAP(60m × 0.32μm) ?? ?? ??? ?

???? ? ? : ????????(FID)

??????? : 70℃?? 5?? ???? ? 5℃/min? ??? 180℃?? ?????.

?????? ?? : 220℃

?????? ?? : 250℃

???????? ? ?? : ??, 0.9mL/min

?(5) ????? : ? ?? 25g(W1)? ??? ?? ????? 50mL? ??????? ??? ?? ??? ??? ???. ?? ? ?? ? ???? ?? ??? ?? ? ??? 98±2℃?? 30?? ??? ?? ??? ???? ?? ? ????? ?? ??? ????? ?? ? ??? ? ??? ??. ???? 20mL? ??? ??? ??? ?? ? ?? ??? ??. ? ??? ???? ?? ?? ????? 4～6??? ???? ????? ????? ??? ???? ???? ? ??? ????(A). ??? ????? 50mL? ?????? ?? ????? 4-6??? ???? ????? ????? ??? ???? ???? ? ? ?? ????(B). ????? 50mL? 250mL ????? ?? ?? ????? 4～6??? ??? ? ????? ????? ??? ???? ? ??? ????. ? ?? 25g(W2)? ?? ?? ??? ?? ? ?? ? ??? ??. ????? ????? ??? ???? ? ??? ????(C). ?? ???? ?? ?????? ??? ?? ?, ? ?? 0.02% ????? ??.

? ? ? ? N = ????? ???? ??(mol/L)

? ? ? ??W1 = ??? ???(g)

? ? ? ??W2 = ???? ??? ???(g)

? ? ? ??A =? ???? ??? ??? ????? ??? ???(mL)

? ? ? ??B =? ??? ??? ??? ??? ????? ??? ???(mL)

? ? ? ??C =? ?? ??? ??? ??? ????? ??? ???(mL)
?

????? ?

?? ????? : ???? ???? ????? ??? ????(1→9).

?? ????? : 4,4’bis-(amino-1-naphthylazo-2,2’-stilbenedisulfonic acid) 0.05g? ????? ?? 0.01g? ??? ?? 60mL ???? ?? ?? 0.1M ???????? 1.5mL? ??? ? ????. ??? ??? 3.5mL? ?? ???? ??? ???? ?? ?? ?? ??? 45mL? ?? ?? ? ? ????.

???????? ??? : ?? 8.5mL? ????? 1000mL? ???? 0.1M ?????? ??? ???? ? 9mL? ??? ???? ??????? ????? ???? ????. ?? ?? ? 48??? ?? ? ???? ?? ?? ??? ??? ??.

?(6) ?????? ? ??????? : ? ??? ?????? ? ???????? ??? ???? ?? ?? ??? ?? ??.

???. ??? 450 ?? ??

??? ?? ? 4.0g? ??? ?? ?? ??? 10mL? ? ?? ?????? ??. ?? ?????? ? ??????? ??? 0.1～0.6g? ??? ?? ? ???? ??? 1～6mg/mL? ??? ??? ?? ??? 100mL? ? ?? ?????? ??. ???? ? ???? 2μL? ?????????? ???? ?? ??? ?? ??? ?, ? ?? ?????? ? ???????? ???? 0.25% ????? ??.

???Esa : ???? 1mL ?? ??????? ?(mg)

???Esb : ???? 1mL ?? ???????? ?(mg)

???Hsa : ?????? ????? ?? ??(mm)

???Hsb : ??????? ????? ?? ??(mm)

???Hta : ???? ? ??????? ?? ??(mm)

???Htb : ???? ? ???????? ?? ??(mm)

??????

??????: ?????????(FID)

????? : ?? 3mm, ?? 1.5m ??????

????????: ? ???? ?? 60～800??? ?????????? ???(Chromosorb W ?? ?? ??? ?)? ??? 12%?? ?? ???? ?? ?

???????? ? ?? : ??(?? ??? ??), 70mL/?

???????: 165℃

????????: 260℃

???. ??? 450 ?? ??

??? ?? ? 50.0g? ??? ?? 250mL ??????? ??? ?????? 75mL? ??? ?? ? ??????? ???? ?? 1～2mm ???? ??? ??? 25mL? ???. ??? ? 25mL? ??? ??? ?? ?? ? ??? ??? ????. ??? ??? ?? ??????? ???? ??? ???? ?? ??? ???? ???? 50mL ???? ?????? ????. ??? ?? ??? ?????? ??? ??? ?????? ??. ?? ??????? ??? 50mg? ??? ?? 25mL ????? ?? ? ??????:?(1:1)? ??? ?? ??? ??????? ??? 25mL? ? ?? ?????? ??. ???? ? ???? 10mL? ?? ????????? 15mL? ???? 50mL ????? ???? ??? ???. 2～5? ??? ?? 450nm?? ???? ????. ??, ????? ????????? 15mL? ??????:? ???(1:1) 10mL? ??? ??? ?? ?? 450nm?? ???? ????. ????? ???? ????? ???? ???? ??? ??.

??????????? : ???????[(NH₄)₂Ce(NO₃)₆] 6.25g? ??? ?? 0.25N ????? ?? 100mL? ??.

?(7) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 1.0ppm ????? ??.

????

? (1) ? ??? ??? ???, ????? ?? ???.

?(2) ??? 1000 ??? ??? ??? ???? 95.0%～105.0%, ??? 1000～7000? ??? ??? ???? 90.0%～110.0%, ??? 7000 ??? ??? ??? ???? 87.5%～112.5%??. ?? ?? ?? 98±2℃? ??? ??? 30～60?? ??? ?? ???? ?? ?, ??????? ?????(1→100) 5??? ?? 0.5M ???????? ????. ? ? ???? ? 15? ?? ???? ???? ???. ?? ?? ???? ???? ?? ??? ???? ?? ???? ???.

????? = 2000W / (B-S)N
?

? ? ? ? W = ??? ??(g)

? ? ? ??B = ????? 0.5M ????????? ???(mL)

? ? ? ??S = ????? 0.5M ????????? ???(mL)

? ? ? ??N = ????????? ????
?

? ???????? : ????? 49g? ???? ?? ?? ??? ??? 300mL? ?? ?, ??? ??? ? ?? ?? ??? ? ? ???? ?? ??? ????.

????? ???????? : ??? ? ??????? 25mL? ?????? ?? ?, ??? ???? 160?? ?? ?? ???? ??? ??? ?? ?(?, PEG 200? ? 1.3g, PEG 600? ? 3.8g) ?? ? ?? ?? ??? ? ???? ?? ? ????.

????? ???????? : ??? ? ??????? 25mL? ?????? ?? ?, ??? ???? 160?? ?? ?? ???? ??? ??? ??? ?? ?? ?? ??????? ?? ??? ??? 25mL? ??? ??? ??? ? ?? ??? ?, ?? ? ?? ?? ??? ? ???? ?? ? ????.

??

? ? ??? ???? 200～9,500?? ?????? ?? ?????.

?????

? ?? 5g? ??? ????????? ?? ??? ?, ? ?? 0.1% ????? ??.

??

Polyethylene glycols are a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene. The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups. The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups. The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides. The average molecular weight of any specific polyethylene glycol product falls within quite narrow limits (°5%). The number of ethylene oxide units or their approximate molecular weight (e.g., PEG-4 or PEG-200) commonly designates the nomenclature of specific polyethylene glycols. Polyethylene glycols with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid. These materials are nonvolatile, water-soluble, tasteless, and odorless. They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.

??? ??

White waxy crystalline flakes

??

Used in conjunction with carbon black to form a conductive composite.1 Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.2

??

Any of several condensa-tion polymers of ethylene glycol with thegeneral formula HOCH2(CH2OCH2)nCH2OH orH(OCH2CH2)nOH. Average molecular weightsrange from 200 to 6000. Properties vary with molec-ular weight.

?? ??

Polyethylene glycol polymers are formed by the reaction of ethylene oxide and water under pressure in the presence of a catalyst.

Indications

Polyethylene glycol (Miralax) is another osmotic laxative that is colorless and tasteless once it is mixed.

?? ??

Clear colorless viscous liquid.

??? ?? ??

Water soluble.

?? ???

Poly(ethylene glycol) is heat-stable and inert to many chemical agents; Poly(ethylene glycol) will not hydrolyze or deteriorate under normal conditions. Poly(ethylene glycol) has a solvent action on some plastics.

????

Poly(ethylene glycol) is combustible.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

????

Like other polymeric substances, polyethylene glycols are not readily biodegradable, with reported 5-day biochemical oxygen demand (BOD5) of 0–1%. However, owing to their hydrophilicity, they have a low potential to bioaccumulate.

??

Polyethylene glycols are chemically stable in air and in solution, although grades with a molecular weight less than 2000 are hygroscopic. Polyethylene glycols do not support microbial growth, and they do not become rancid.
Polyethylene glycols and aqueous polyethylene glycol solutions can be sterilized by autoclaving, filtration, or gamma irradiation.
Sterilization of solid grades by dry heat at 150℃ for 1 hour may induce oxidation, darkening, and the formation of acidic degradation products. Ideally, sterilization should be carried out in an inert atmosphere. Oxidation of polyethylene glycols may also be inhibited by the inclusion of a suitable antioxidant.
If heated tanks are used to maintain normally solid polyethylene glycols in a molten state, care must be taken to avoid contamination with iron, which can lead to discoloration. The temperature must be kept to the minimum necessary to ensure fluidity; oxidation may occur if polyethylene glycols are exposed for long periods to temperatures exceeding 50℃. However, storage under nitrogen reduces the possibility of oxidation.
Polyethylene glycols should be stored in well-closed containers in a cool, dry place. Stainless steel, aluminum, glass, or lined steel containers are preferred for the storage of liquid grades.

? ???

The chemical reactivity of polyethylene glycols is mainly confined to the two terminal hydroxyl groups, which can be either esterified or etherified. However, all grades can exhibit some oxidizing activity owing to the presence of peroxide impurities and secondary products formed by autoxidation.
Liquid and solid polyethylene glycol grades may be incompatible with some coloring agents.
The antibacterial activity of certain antibiotics is reduced in polyethylene glycol bases, particularly that of penicillin and bacitracin. The preservative efficacy of the parabens may also be impaired owing to binding with polyethylene glycols.
Physical effects caused by polyethylene glycol bases include softening and liquefaction in mixtures with phenol, tannic acid, and salicylic acid. Discoloration of sulfonamides and dithranol can also occur, and sorbitol may be precipitated from mixtures. Plastics, such as polyethylene, phenolformaldehyde, polyvinyl chloride, and cellulose-ester membranes (in filters) may be softened or dissolved by polyethylene glycols. Migration of polyethylene glycol can occur from tablet film coatings, leading to interaction with core components.

Regulatory Status

Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; ophthalmic preparations; oral capsules, solutions, syrups, and tablets; rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

????????#300 ?? ?? ? ???

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????????#300 ?? ??

???	??	???	??	?? ?	??
ChemFine International Co.,Ltd.	+86-510-82753588 +86-13806194144	info@chemfineinternational.com	China	300	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Biopole Pharmatech Co., Ltd.	+8615151475053	biopole@163.com	China	37	58
WUHAN JADECHEM INTERNATIONAL TRADE CO.,LTD	+86-83527060 +86-13972901456	sales03@jadechem-intl.com	China	84	58
Yujiang Chemical (Shandong) Co.,Ltd.	+86-17736087130 +86-18633844644	catherine@yjchem.com.cn	China	990	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18151	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	3010	58

????????#300 ?? ??: